REV3L Antibody

1. Following challenge with AFB1, survival of mouse cells deficient in pol zeta (Rev3L(-/-)) was significantly reduced relative to Rev3L(+/-) cells or Rev3L(-/-) cells complemented through expression of the wild-type human REV3L PMID: 27849610
2. These results demonstrate a previously unrecognized relationship between p53 and REV3L in cancer cell metabolism and may lead to improvements in chemotherapy treatment plans that reduce cisplatin resistance in lung cancer. PMID: 29307819
3. REV3/ATR knockdown enhances the cytotoxicity of cisplatin in non-small cell lung cells. PMID: 28075014
4. The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase. PMID: 27095204
5. The results indicate that human DNA polymerase zeta plays important roles in induction of mutations, clastogenicity and in cellular survival of the damaged human cells. PMID: 27338670
6. loss-of-function of REV3L dramatically enhanced the sensitivity of SCCHN cells to dacomitinib by the loss of both translesion synthesis and homologous recombination pathways. PMID: 26790612
7. REV3L plays an important role in esophageal squamous cell carcinoma (ESCC) progression and chemoresistance, and is a potential diagnostic marker and therapeutic target for ESCC PMID: 26752104
8. REV3 functions in mammalian mitochondria and that mitochondrial REV3 is associated with the tumorigenic potential of cells. PMID: 26462070
9. Taken together, we demonstrated that inhibition of REV3L sensitized lung cancer H1299 cells to cisplatin treatment PMID: 26165320
10. finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS patients suggests that de novo mutations in other genes might account for other MBS patients PMID: 26068067
11. data suggest that REV3L plays an important role in regulating cervical cancer cellular response to cisplatin PMID: 25781640
12. Rev3, the catalytic subunit of polymerase zeta (Pol zeta), is involved in DNA replication under conditions of replication stress caused by deoxyribonucleotide shortage and/or imbalance in human lung adenocarcinoma cells. PMID: 25113059
13. Single nucleotide polymorphisms in RBPJ, IL1R1, REV3L, TRAF3IP2, IRF1 and ICOS showed association with rheumatoid arthritis in black South Africans. PMID: 25014791
14. Our results suggest for the first time that REV1 and REV3L SNPs might serve as potential predictive markers of outcome of cisplatin-based chemotherapy PMID: 24956248
15. Human Pol eta inserts a nucleotide opposite the lesion, followed by Pol zeta extending the DNA primer; thus, the two complement each other to fully bypass the cisplatin cross-link. PMID: 24449906
16. DNA polymerase zeta is a predictor of poor prognosis for cervical cancer patients who are resistant to chemoradiation. PMID: 23456618
17. A long-term depletion of Rev3 in cultured human cells results in massive genomic instability and severe cell cycle arrest. PMID: 23303771
18. REV3L rs465646 variant modifies lung cancer susceptibility in Chinese Han population by affecting miRNA-mediated gene regulation PMID: 22349819
19. analysis of the crystal structure of the ternary complex composed of the C-terminal domain of human REV1, REV7, and a REV3 fragment PMID: 22859296
20. ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment has been crystallized. The crystals belonged to space group P3(1)21, with unit-cell parameters a = b = 74.7, c = 124.5 A PMID: 22869133
21. our data suggest a significant role of genetic variation in the polymerase zeta subunit genes regarding the development and progression of BC. PMID: 21455670
22. DNA polymerase zeta transgene participates directly in immunoglobulin hypermutation. PMID: 22547703
23. REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus. PMID: 22303021
24. The REV1/Polzeta complex maintains genomic stability by directly participating in DNA double-stranded break repair. PMID: 21926160
25. Findings indicate that depletion of REV3 not only can amend cisplatin-based cancer therapy but also can be applied for susceptible cancers as a potential monotherapy. PMID: 22028621
26. Data suggest that REV3 plays an important role in different cellular growth periods and physiological conditions. PMID: 20466635
27. function of REV7 as an adapter protein to recruit Polzeta to a DNA lesion site PMID: 20164194
28. show the first crystal structure of REV7 in complex with a fragment of REV3 polymerase (residues 1847-1898) and reveal the mechanism underlying REV7-REV3 interaction PMID: 20164194
29. REV1 and Polzeta facilitate repair of interstrand cross-links independently of PCNA monoubiquitination and Poleta, whereas RAD18 plus Poleta, REV1, and Polzeta are all necessary for replicative bypass of cisplatin intrastrand DNA cross-links. PMID: 20028736
30. To clarify the structural basis of the interaction between REV7 and REV3, REV7 was crystallized in complex with a REV3 fragment. PMID: 20054135
31. REV3L Overexpression confers chemoresistance to cisplatin in gliomas. PMID: 19289490
32. plays a critical role in the induction of mutations PMID: 12459444
33. REV3 gene plays a role not only in lesion-targeted DNA mutagenesis, but also in mutagenesis on undamaged DNA templates that is called untargeted mutation. PMID: 12717825
34. downregulation of rev3 might have occurred early during tumorigenesis. PMID: 18622427
35. The study revealed that suppression of REV3 delayed spontaneous S phase progression and suppression of REV3 limits spontaneous and DNA damage induced mutagenesis. PMID: 18779149
36. DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from xeroderma pigmentosum variant patients. PMID: 19564618

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HGNC: 9968

OMIM: 602776

KEGG: hsa:5980

STRING: 9606.ENSP00000351697

UniGene: Hs.232021