Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RGS1 Polyclonal antibody

Uniprot No.

Q08116

Target Names

RGS1

Alternative Names

1R20 antibody; B cell activation protein BL34 antibody; B-cell activation protein BL34 antibody; BL34 antibody; Early response protein 1R20 antibody; IER 1 antibody; IER1 antibody; Immediate early response 1 B cell specific antibody; immediate-early response 1, B-cell specific antibody; IR20 antibody; Regulator of G protein signalling 1 antibody; Regulator of G-protein signaling 1 antibody; RGS 1 antibody; RGS1 antibody; RGS1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Regulator of G-protein signaling 1 protein (14-209AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Gene References into Functions

Results showed that RGS1 expression was significantly higher in melanoma than that noted in nevus tissue and correlated with reduced diseasespecific survival. Also, RGS1 expression was also found to be related to the proliferation and migration of melanoma cells through regulation of Galphasmediated inactivation of AKT and ERK. PMID: 29620236
The rs12022418 in RGS1 showed novel associations in IgA nephropathy. PMID: 27804980
High RGS1 immunohistochemistry expression associates with poor overall survival in diffuse large B cell lymphoma PMID: 27775850
RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new multiple myeloma therapy. PMID: 27445341
Regulator of G-protein signaling 1 rs2816316 was negatively associated with celiac disease . PMID: 27043536
RGS1 as a potential marker of CRC tissue quality PMID: 26222051
RGS1 suppresses CXCL12-mediated migration and AKT activation in cultured human plasmacytoma cells and plasmablasts. PMID: 25897806
Rgs1 has a role in leukocyte trafficking and vascular inflammation PMID: 25782711
RGS1 and TNFRSF1A polymorphisms tended to be associated with reduced attack severity in Multiple sclerosis. PMID: 24130709
RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies PMID: 23464602
Markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders. PMID: 23324853
Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines PMID: 21795595
RGS1 is a novel multiple sclerosis susceptibility loci, shared with celieac disease. PMID: 20555355
Overexpression of RGS1 in progenitor pro-B cells (which have little endogenous RGS1) impairs CXCL12-induced focal adhesion kinase activation, chemotaxis, and adhesion to membrane domains. PMID: 15728464
RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway. PMID: 16565322
RGS1 is (over-) expressed in a broad variety of malignancies PMID: 18301890
Results validate the role of RGS1 as a novel prognostic marker for melanoma given its impact on the survival associated with melanoma. PMID: 18580492
Undifferentiated spondylarthritis (uSpA) peripheral blood mononuclear cells (PBMCs) carry more expressed genes than PBMCs from ankylosing spondylitis (AS) patients. TNFalpha- and IL-17-inducible RGS1 is a biomarker for uSpA, and to a lesser extent for AS. PMID: 19877080

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Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.

Tissue Specificity

Detected in peripheral blood monocytes. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.

Database Links

HGNC: 9991

OMIM: 600323

KEGG: hsa:5996

STRING: 9606.ENSP00000356429

UniGene: Hs.75256