RGS3 Antibody

1. It has been reported that mitotic kinesin KIF20A interacts with RGS3 and plays a crucial role in controlling the division modes of neural progenitor cells during cortical neurogenesis. PMID: 30006548
2. Findings suggest that overexpressed RGS3 regulated by microRNA-126 through the post-transcriptional modulation is associated significantly with a poor prognosis of GC patients. PMID: 27754994
3. Our data provide a novel miR-25/RGS3 signal in the development of lung cancer. PMID: 26416661
4. cardiac overexpression of RGS3 inhibits maladaptive hypertrophy and fibrosis and improves cardiac function by blocking MEK-ERK1/2 signaling PMID: 24375609
5. PDZ-RGS3 can enhance signals generated by the Wnt canonical pathway and plays a pivotal role in epithelial mesenchymal transition PMID: 22859293
6. Results suggest that the 14-3-3 protein binding affects the structure of the Galpha interaction portion of RGS3 as well as sterically blocks the interaction between the RGS domain and the Galpha subunit of heterotrimeric G proteins. PMID: 22027839
7. 14-3-3 protein binding induces structural changes in both the N-terminal part and the C-terminal RGS domain of phosphorylated RGS3 molecule PMID: 20347994
8. Regulator of G-protein signalling 3 (RGS3) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure. PMID: 19778949
9. Data are consistent with the model wherein 14-3-3 serves as a scavenger of RGS3, regulating the amounts of RGS3 available for binding G-proteins. PMID: 11985497
10. C2PA is expressed in the cell nucleus and induces heat shock response element (HSE)-dependent gene transcription PMID: 12210723
11. RFS3 promoted the conversion of more stable Ca2+ elevations into oscillatory signals. PMID: 15383626
12. mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. PMID: 16821082
13. Full-length RGS3, RGS3T, and the core domain of RGS3 were equally effective in antagonizing inhibition of Ca(V)2.3 through M(2)R. PMID: 16855219
14. This study identifies a novel, noncanonical role of RGS3 in regulation of TGF-beta signaling through its interaction with Smads and interfering with Smad heteromerization. PMID: 18287247
15. in apoptosis-initiated cells, the ligand-dependent C5aR-mediated dual signal affects the fate of cells, either apoptosis execution or survival, through regulation of RGS3 gene expression and subsequent modulation of ERK signal. PMID: 19333232

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HGNC: 9999

OMIM: 602189

KEGG: hsa:5998

STRING: 9606.ENSP00000259406

UniGene: Hs.494875