RHOBTB3 Antibody, HRP conjugated

Code CSB-PA019686LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RHOBTB3 Polyclonal antibody
Uniprot No.
Target Names
RHOBTB3
Alternative Names
RHOBTB3 antibody; KIAA0878 antibody; Rho-related BTB domain-containing protein 3 antibody; EC 3.6.1.- antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Rho-related BTB domain-containing protein 3 protein (251-500AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.
Gene References into Functions
  1. RHOBTB3 serves as a scaffold to organize a multi-subunit complex that promotes the hydroxylation, ubiquitination and degradation of HIFalpha. PMID: 26215701
  2. Reveal a novel role for a RhoBTB3 in catalyzing cyclin E turnover during S phase, as well as an unexpected, essential role for the Golgi as a ubiquitylation platform for cell cycle control. PMID: 24145166
  3. The interaction between RhoBTB3 and the 5-HT7a receptor strongly inhibits proteasomal degradation of the 5-HT7a receptor. PMID: 22245496
  4. Study reports that the atypical Rho GTPase family member, RhoBTB3, binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. PMID: 19490898
Subcellular Location
Golgi apparatus.
Tissue Specificity
Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis.
Database Links

HGNC: 18757

OMIM: 607353

KEGG: hsa:22836

STRING: 9606.ENSP00000369318

UniGene: Hs.445030

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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