RIC8A Antibody

Datasheet

Code	CSB-PA878847ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA878847ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA878847ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RIC8A Polyclonal antibody

Uniprot No.

Q9NPQ8

Target Names

RIC8A

Alternative Names

MGC104517 antibody; MGC131931 antibody; MGC148073 antibody; MGC148074 antibody; Protein Ric-8A antibody; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) antibody; RIC8 antibody; RIC8A antibody; RIC8A_HUMAN antibody; Synembryn-A antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Synembryn-A protein (362-531AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Gene References into Functions

Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2. PMID: 25074811
Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha(i/o)-GDP complex in a cellular environment. PMID: 25480567
Ric-8A co-localized with Vps34 at the midbody. PMID: 24466196
The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A. PMID: 23665327
NCAM180 regulates Ric8A membrane localization and potentiates beta-adrenergic response PMID: 22384181
RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A PMID: 21880739
Ric-8A is critical for growth factor receptor-induced actin cytoskeletal reorganization PMID: 21771786
Ric-8A signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle. PMID: 20479129

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Subcellular Location

Cytoplasm. Cell membrane.

Protein Families

Synembryn family

Database Links

HGNC: 29550

OMIM: 609146

KEGG: hsa:60626

STRING: 9606.ENSP00000325941

UniGene: Hs.592292

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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