RLN3 Antibody

1. Serum level of relaxin-3 hormone is an important mediator in the pathophysiological process of normal puberty being significantly decreased in males with delayed puberty. PMID: 28786126
2. Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research. PMID: 27498038
3. the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3, to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3, respectively. PMID: 27193232
4. In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting. PMID: 27488261
5. the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 PMID: 27353281
6. Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5. PMID: 27888281
7. Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour. PMID: 26272327
8. Review of research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion. PMID: 24988606
9. we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor PMID: 24641548
10. Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3. PMID: 24615237
11. Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4. PMID: 24802387
12. Relaxin-2 or relaxin-3 levels are not related to component traits in patients with diabetes. PMID: 23994775
13. metabolic syndrome is associated with increased serum relaxin-3 levels in women PMID: 23018057
14. [review] Relaxin-3 (RXF3P) is expressed within GABA neurons of the brainstem including an area known as the nucleus incertus; ascending relaxin-3 projections innervate a broad range of RXFP3-rich forebrain areas. PMID: 21693186
15. H3 relaxin exerts antifibrotic actions via RXFP1 receptor PMID: 21229994
16. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. PMID: 19778557
17. relaxin-3/INSL7 is a ligand for GPCR142 PMID: 14522967
18. GPCR135 is the receptor for relaxin-3 PMID: 14522968
19. RLN3 chimeric peptide is a potential tool to study in vivo function of GPCR135. PMID: 15465925
20. Intracerebroventricular injections of human relaxin-3 (H3) to satiated rats significantly increased food intake. PMID: 15845619
21. NMR spectroscopy and simulated annealing calculations were used to determine the three-dimensional structure of relaxin-3 and to identify key structural differences between the human relaxins. PMID: 15956686
22. functional response to H3 relaxin and other relaxin/insulin peptides of GPCR135 expressed in CHO-K1 cells was measured in the cytosensor microphysiometer and analyzed using inhibitors of signal transduction proteins PMID: 15956730
23. Results describe the solution structure of human relaxin-3. PMID: 16365033
24. Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3. PMID: 19152634

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HGNC: 17135

OMIM: 606855

KEGG: hsa:117579

STRING: 9606.ENSP00000397415

UniGene: Hs.352155