RNASEH2A Antibody

Datasheet

Code	CSB-PA019805LA01HU
Size	US$166
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Image	IHC image of CSB-PA019805LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RNASEH2A Polyclonal antibody

Uniprot No.

O75792

Target Names

RNASEH2A

Alternative Names

RNASEH2A antibody; RNASEHI antibody; RNHIA antibody; Ribonuclease H2 subunit A antibody; RNase H2 subunit A antibody; EC 3.1.26.4 antibody; Aicardi-Goutieres syndrome 4 protein antibody; AGS4 antibody; RNase H(35) antibody; Ribonuclease HI large subunit antibody; RNase HI large subunit antibody; Ribonuclease HI subunit A antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ribonuclease H2 subunit A protein (201-299AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RNASEH2A Antibody (Product code: CSB-PA019805LA01HU) is Non-conjugated. For RNASEH2A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA019805LB01HU	RNASEH2A Antibody, HRP conjugated	ELISA
FITC	CSB-PA019805LC01HU	RNASEH2A Antibody, FITC conjugated
Biotin	CSB-PA019805LD01HU	RNASEH2A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

Gene References into Functions

The expression levels of RNASEH2A, CDK1, and CD151 and their combination could predict the survival of renal cell carcinoma patients. PMID: 29843367
RNaseH2A may be involved in human gliomagenesis. PMID: 27176716
This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2A in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner. PMID: 24986920
Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA. PMID: 25703292
study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype PMID: 23592335
analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome PMID: 21454563

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Involvement in disease

Aicardi-Goutieres syndrome 4 (AGS4)

Subcellular Location

Nucleus.

Protein Families

RNase HII family, Eukaryotic subfamily

Database Links

HGNC: 18518

OMIM: 606034

KEGG: hsa:10535

STRING: 9606.ENSP00000221486

UniGene: Hs.532851

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Service

Phage Display Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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