RND1 Antibody

Code CSB-PA835694LA01HU
Size US$166
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Image
  • IHC image of CSB-PA835694LA01HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of A549 cells with CSB-PA835694LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RND1 Polyclonal antibody
Uniprot No.
Target Names
RND1
Alternative Names
ARHS antibody; FLJ42294 antibody; GTP binding protein RHO6 antibody; Ras homolog gene family member S antibody; RHO 6 antibody; Rho family GTPase 1 antibody; Rho related GTP binding protein Rho6 antibody; RHO S antibody; Rho-related GTP-binding protein Rho6 antibody; RHO6 antibody; RHOS antibody; RND 1 antibody; Rnd1 antibody; RND1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Rho-related GTP-binding protein Rho6 protein (1-106AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RND1 Antibody (Product code: CSB-PA835694LA01HU) is Non-conjugated. For RND1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA835694LB01HU RND1 Antibody, HRP conjugated ELISA
FITC CSB-PA835694LC01HU RND1 Antibody, FITC conjugated
Biotin CSB-PA835694LD01HU RND1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
Gene References into Functions
  1. Reduced RND1 expression in HCC was associated with cancer progression, likely through regulation of the Ras signaling pathway. PMID: 27770342
  2. Studies suggest that Rho GTPase signalling is a complicated mechanism in RhoA-driven cancer cell invasive migration. PMID: 27913679
  3. RND1 plays an important role in the progression of esophageal squamous cell carcinoma PMID: 26250459
  4. These results reveal a previously unappreciated mechanism through which Rnd1 restrains activation of Ras-MAPK signalling and breast tumour initiation and progression PMID: 25531777
  5. Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa. PMID: 23603360
  6. role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation PMID: 22357615
  7. Rnd1 does not play a role in the activation of plexin-C1 and -D1 PMID: 21610070
  8. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers PMID: 11940653
  9. The RND1 mRNA expression levels increased significantly after gestation in myometria. PMID: 16311049
  10. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain PMID: 17916560

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Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein Families
Small GTPase superfamily, Rho family
Tissue Specificity
Mostly expressed in brain and liver.
Database Links

HGNC: 18314

OMIM: 609038

KEGG: hsa:27289

STRING: 9606.ENSP00000308461

UniGene: Hs.124940

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