RND1 Antibody

1. Reduced RND1 expression in HCC was associated with cancer progression, likely through regulation of the Ras signaling pathway. PMID: 27770342
2. Studies suggest that Rho GTPase signalling is a complicated mechanism in RhoA-driven cancer cell invasive migration. PMID: 27913679
3. RND1 plays an important role in the progression of esophageal squamous cell carcinoma PMID: 26250459
4. These results reveal a previously unappreciated mechanism through which Rnd1 restrains activation of Ras-MAPK signalling and breast tumour initiation and progression PMID: 25531777
5. Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa. PMID: 23603360
6. role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation PMID: 22357615
7. Rnd1 does not play a role in the activation of plexin-C1 and -D1 PMID: 21610070
8. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers PMID: 11940653
9. The RND1 mRNA expression levels increased significantly after gestation in myometria. PMID: 16311049
10. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain PMID: 17916560

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HGNC: 18314

OMIM: 609038

KEGG: hsa:27289

STRING: 9606.ENSP00000308461

UniGene: Hs.124940