RPA4 Antibody

Code CSB-PA16249A0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RPA4 Polyclonal antibody
Uniprot No.
Target Names
RPA4
Alternative Names
HSU24186 antibody; MGC120333 antibody; MGC120334 antibody; p30 antibody; Replication factor A protein 4 antibody; Replication protein A 30 kDa subunit antibody; RF A antibody; RF-A protein 4 antibody; RFA antibody; RFA4_HUMAN antibody; RP A antibody; RP-A p30 antibody; RPA antibody; RPA4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Replication protein A 30 kDa subunit protein (1-260AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RPA4 Antibody (Product code: CSB-PA16249A0Rb) is Non-conjugated. For RPA4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA16249B0Rb RPA4 Antibody, HRP conjugated ELISA
FITC CSB-PA16249C0Rb RPA4 Antibody, FITC conjugated
Biotin CSB-PA16249D0Rb RPA4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Gene References into Functions
  1. Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells. PMID: 19996105
  2. Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell. PMID: 19942684
  3. Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage. PMID: 15929725
Subcellular Location
Nucleus. Note=Localizes to DNA repair foci after DNA damage.
Protein Families
Replication factor A protein 2 family
Tissue Specificity
Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels.
Database Links

HGNC: 30305

OMIM: 300767

KEGG: hsa:29935

STRING: 9606.ENSP00000362131

UniGene: Hs.659349

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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