RUSC1 Antibody

Code CSB-PA871585LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA871585LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA871585LA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA871585LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RUSC1 Polyclonal antibody
Uniprot No.
Target Names
RUSC1
Alternative Names
RUSC1 antibody; NESCARUN and SH3 domain-containing protein 1 antibody; New molecule containing SH3 at the carboxy-terminus antibody; Nesca antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human RUN and SH3 domain-containing protein 1 protein (231-433AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RUSC1 Antibody (Product code: CSB-PA871585LA01HU) is Non-conjugated. For RUSC1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA871585LB01HU RUSC1 Antibody, HRP conjugated ELISA
FITC CSB-PA871585LC01HU RUSC1 Antibody, FITC conjugated
Biotin CSB-PA871585LD01HU RUSC1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth. May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
Gene References into Functions
  1. RUN domain of NESCA can bind H-Ras, a downstream signaling molecule of TrkA, with high affinity. Moreover, NESCA RUN can directly interact with TrkA. PMID: 22821014
  2. Nesca functions as an adapter involved in neuronal vesicular transport PMID: 22404429
  3. Data show that NESCA and NEMO interact by their N-terminal region, that NESCA directly associates with TRAF6, which in turn catalyzes NESCA polyubiquitination, and that NESCA overexpression strongly inhibits TRAF6-mediated polyubiquitination of NEMO. PMID: 19365808
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Early endosome. Cell junction, synapse, postsynaptic density. Golgi apparatus.
Tissue Specificity
Predominantly expressed in brain.
Database Links

HGNC: 17153

OMIM: 617318

KEGG: hsa:23623

STRING: 9606.ENSP00000357336

UniGene: Hs.226499

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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