SASH1 Antibody

1. findings suggested that SASH1 can be useful as a new prognostic marker and therapeutic target in cervical cancer patients. PMID: 28975991
2. Data show that SAM and SH3 domain containing 1 protein (SASH1) binds with mitogen-activated protein kinase kinase 2 (MAP2K2), and SASH1 mutations promote binding between SASH1 and MAP2K2. PMID: 28382689
3. SASH1 is prognostic in breast cancer and could have subtype-dependent effects on breast cancer progression. PMID: 27637080
4. SASH1 may inhibit hepatocarcinoma cell invasion and metastasis through down-regulating the Shh-Gli1 and PI3K-AKT pathways PMID: 28600143
5. Case Report: SASH1 missense mutation in a Chinese Family with multiple lentigines. PMID: 27840890
6. SASH1 acts through NOTCH1 and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1. PMID: 28823832
7. SASH1 is cleaved by caspase-3 following Ultraviolet C-induced apoptosis. PMID: 27831555
8. a novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. PMID: 27885802
9. Overexpression of SASH1 inhibits TGF-beta1-induced EMT. PMID: 27178818
10. Overexpression of SASH1 suppressed the expression of Shh. PMID: 27178819
11. The loss or inhibition of SASH1 expression may play an important role in thyroid cancer development, invasion, and metastasis. PMID: 26722413
12. Two SNPs were significantly associated with rotator cuff tearing, residing in SAP30BP on chromosome 17 and SASH1 on chromosome 6. PMID: 26350878
13. SASH1 expression is increased in atherosclerotic carotids in smokers and its silencing affects endothelial angiogenic functions PMID: 26318107
14. SASH1 expression strongly correlated with glioma grades, showing higher expression at a lower grade. PMID: 26424902
15. Data suggest that SASH1 (SAM and SH3 domain-containing protein 1) should be added to the list of genes responsible for autosomal-dominant and -recessive genodermatosis. PMID: 25315659
16. SASH1 Is Involved in an Autosomal Dominant Lentiginous Phenotype. PMID: 26203640
17. Propose that increase of DNA methylation level in the promoter region of gene SASH1, particularly CpG_26.27 or CpG_54.55 sites, possibly repressed SASH1 expression in breast cancer. PMID: 24344014
18. The SASH1 gene is blocked cyclin B1-Cdc2 binding, either directly or indirectly, leading to G2/M arrest. PMID: 23023727
19. SASH1 regulates IQGAP1-E-Cadherin signalling and crosstalking between GPCR signalling, calmodulin signalling for the modulation of melanocytes invasion. PMID: 23333244
20. Overexpression of SASH1 might be associated with the inhibition of growth, proliferation, and invasion osteosarcoma cells. PMID: 23108792
21. Loss of SASH1 is associated with glioma. PMID: 22915266
22. The SASH1 gene may inhibit A549 cell growth and proliferation as well as promote cellular apoptosis. The overexpression of the SASH1 gene may also be related to the decreased migration of A549 human lung cancer cells. PMID: 22488244
23. A mechanistic role for SASH1 in tumor formation by regulating the adhesive and migratory behavior of cancer cells has been shown. PMID: 21820526
24. tumor suppressor gene possibly involved in tumorigenesis of breast and other solid cancers PMID: 12771949
25. Downregulated expression of the candidate tumour suppressor gene SASH1 is associated with colon cancer PMID: 17088907

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HGNC: 19182

OMIM: 607955

KEGG: hsa:23328

STRING: 9606.ENSP00000356437

UniGene: Hs.193133