SCG3 Antibody, HRP conjugated

Code CSB-PA845166LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SCG3 Polyclonal antibody
Uniprot No.
Target Names
SCG3
Alternative Names
1B1075 antibody; AI385542 antibody; Chgd antibody; SCG3 antibody; SCG3_HUMAN antibody; Secretogranin III antibody; Secretogranin-3 antibody; SGCG antibody; SgIII antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Secretogranin-3 protein (205-432AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
Gene References into Functions
  1. This review summarizes our current knowledge of Scg3 as a regulatory protein of secretory granules, highlights its new role as a highly disease-selective angiogenic factor, and envisions Scg3 inhibitors as "selective angiogenesis blockers" for targeted therapy of diabetic retinopathy. [review] PMID: 28856381
  2. results suggested an association between the fucosylated glycoform of short-form SgIII and Small Cell Lung Carcinoma PMID: 28949141
  3. SCG3 is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested PMID: 22998035
  4. SCG3 may be involved in apoptosis signal transduction as a caspase substrate.It may be a pivotal component of the neuroendocrine pathway & play an important role in neuronal communication & neurotransmitter release. PMID: 22987761
  5. Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome. PMID: 21796137
  6. This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs) II and III. PMID: 21046454
  7. SgIII was expressed in 41 of 47 neuroendocrine tumours. The expression of SgIII agreed well with that of CgA, CgB and SgII, with exceptions of phaeochromocytomas and parathyroid adenomas. PMID: 20550951
  8. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion. PMID: 17200173
  9. Secretogranins III assays failed to detect increased concentrations in any of the patients with neuroendocrine tumours. PMID: 18448176

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Subcellular Location
Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted.
Tissue Specificity
Expressed in brain, heart, kidney, liver and skeletal muscle.
Database Links

HGNC: 13707

OMIM: 611796

KEGG: hsa:29106

STRING: 9606.ENSP00000220478

UniGene: Hs.232618

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