SCN7A Antibody

Code CSB-PA779166
Size US$297
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  • Immunofluorescence analysis of A549 cells, using SCN7A antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SCN7A Polyclonal antibody
Uniprot No.
Target Names
SCN7A
Alternative Names
SCN7A antibody; SCN6A antibody; Sodium channel protein type 7 subunit alpha antibody; Putative voltage-gated sodium channel subunit alpha Nax antibody; Sodium channel protein cardiac and skeletal muscle subunit alpha antibody; Sodium channel protein type VII subunit alpha antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human SCN7A.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IF
Recommended Dilution
Application Recommended Dilution
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Gene References into Functions
  1. The authors demonstrated that the sodium channel Nax functions as a sodium sensor. With increased extracellular sodium, Nax up-regulates prostasin, which results in activation of the sodium channel ENaC. PMID: 26537257
  2. SNP rs7565062 of SCN7A was significantly associated with essential hypertension in a Northern Han Chinese population PMID: 25393565
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Sodium channel (TC 1.A.1.10) family, SCN7A subfamily
Tissue Specificity
Heart and uterus.
Database Links

HGNC: 10594

OMIM: 182392

KEGG: hsa:6332

STRING: 9606.ENSP00000386796

UniGene: Hs.596087

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