SDC3 Antibody

Code CSB-PA020890GA01HU
Size US$685
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Product Details

Uniprot No. O75056
Target Names SDC3
Alternative Names N-syndecan antibody; Sdc3 antibody; SDC3_HUMAN antibody; SDCN antibody; SYND3 antibody; Syndecan neural type antibody; syndecan proteoglycan 3 antibody; Syndecan-3 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human SDC3
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,IHC,IF
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
Gene References into Functions
  1. High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and perineural invasion in the orthotopic mouse model of pancreatic cancer. PMID: 28638231
  2. Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells PMID: 25617766
  3. Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions. PMID: 24956062
  4. frequently expressed in pancreatic cancer and associated with perineural invasion PMID: 24659893
  5. Syndecan-3 expression was not associated with disease progression and outcome in specific subtypes of mammary carcinoma. PMID: 23351331
  6. SDC3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
  7. Syndecan-3 may directly transduce Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET. PMID: 21200028
  8. These findings indicate that SDC3 polymorphisms could contribute to the link between female hyperandrogenism and obesity and suggest a novel potential role for SDC3 as a modulator of gonadal steroid function. PMID: 19820907
  9. Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy. PMID: 11968010
  10. Selective induction of CXCL8 binding site on endothelial syndecan-3 in rheumatoid arthritis(RA) synovium. This site may be involved in leukocyte trafficking into RA synovial tissue. PMID: 16052590
  11. The high expression of syndecan 3 and its localization to the smooth muscle bundles during normal labour, together with the significant reduction in prolonged labour, may indicate a role for this protein in the co-ordination of myometrial contractility. PMID: 16674815
  12. There are ethnic differences in the SDC3 polymorphisms, and the polymorphisms are strongly associated with obesity. PMID: 17018662
  13. Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen PMID: 17368428
  14. Syndecan-3 was identified as a major HIV-1 attachment receptor on DCs. PMID: 18040049
  15. syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context PMID: 18093920
  16. pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30. PMID: 18599487
  17. found in 57.9% of pancreatic ductal carcinoma specimens PMID: 18716876
  18. Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours. PMID: 19822079

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Syndecan proteoglycan family
Tissue Specificity Expressed in the nervous system, the adrenal gland, and the spleen.
Database Links

HGNC: 10660

OMIM: 186357

KEGG: hsa:9672

STRING: 9606.ENSP00000344468

UniGene: Hs.158287

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