SDCCAG8 Antibody

Datasheet

Code	CSB-PA006722
Size	US$100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q86SQ7

Target Names

SDCCAG8

Alternative Names

Antigen NY CO 8 antibody; Antigen NY-CO-8 antibody; BBS16 antibody; CCCAP antibody; CCCAP SLSN7 antibody; Centrosomal colon cancer autoantigen protein antibody; hCCCAP antibody; HSPC085 antibody; NPHP10 antibody; NPHP10 gene antibody; NY-CO-8 antibody; Sdccag8 antibody; SDCG8_HUMAN antibody; Serologically defined colon cancer antigen 8 antibody; Serologically defined colon cancer antigen 8 homolog antibody; SLSN7 antibody; SLSN7 gene antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the C-terminal region of Human NY-CO-8.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:20000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Plays a role in the establishment of cell polarity and epithelial lumen formation. Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis.

Gene References into Functions

Variants in NPHS2, SDCCAG8 and near BMP4 appear to interact with APOL1 to modulate the risk for non-diabetic end stage kidney disease in african americans. PMID: 24157943
significant associations in schizophrenia to SDCAAG8 and extensive replication of associations reported by the Schizophrenia. PMID: 22614287
Our results and prior literature suggest that SDCCAG8 could play an important role in presumed Bardet-Biedl syndrome (BBS) patients affected with severe kidney disease and absent polydactyly. PMID: 22626039
Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement. PMID: 22095114
Mutation of SDCCAG8 is associated with retinal-renal ciliopathy. PMID: 20835237

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Involvement in disease

Senior-Loken syndrome 7 (SLSN7); Bardet-Biedl syndrome 16 (BBS16)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cell junction. Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle.; [Isoform 2]: Cytoplasm.

Tissue Specificity

Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors.

Database Links

HGNC: 10671

OMIM: 613524

KEGG: hsa:10806

STRING: 9606.ENSP00000355499

UniGene: Hs.591530

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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