SEPT12 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA809019LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SEPT12 Polyclonal antibody

Uniprot No.

Q8IYM1

Target Names

SEPT12

Alternative Names

SEP12_HUMAN antibody; SEPT12 antibody; Septin-12 antibody; Septin12 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Septin-12 protein (1-358AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Filament-forming cytoskeletal GTPase. Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential).

Gene References into Functions

results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility. PMID: 25588830
we discovered that the SEPTIN12-microtubule complexes are critical for sperm formation during spermiogenesis PMID: 24213608
SEPTIN12 genetic variants confer susceptibility to teratozoospermia PMID: 22479503
Eight coding single-nucleotide polymorphisms in SEPTIN12 were detected in the patients with Sertoli cell-only syndrome. Analysis of the results suggest that SEPTIN12 might play a critical role in human spermatogenesis. PMID: 21636737
SEPT12 mutations cause male infertility with defective sperm annulus and disrupt sperm structural integrity PMID: 22275165
The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest PMID: 22116646
While SEPT12 formed filamentous structures at interphase, it was localized to the central spindle and to midbody during anaphase and cytokinesis, respectively. PMID: 18047794
Decreases in SEPTIN12 expression is associated with male infertility. PMID: 19359518

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Involvement in disease

Spermatogenic failure 10 (SPGF10)

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Nucleus. Cell projection, cilium, flagellum.

Protein Families

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family

Tissue Specificity

Widely expressed. Expressed in lymph node.

Database Links

HGNC: 26348

OMIM: 611562

KEGG: hsa:124404

STRING: 9606.ENSP00000268231

UniGene: Hs.126780

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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