SELENOW Antibody, HRP conjugated

1. The SS concentrations that lead to a decrease in the viability of human prostate adenocarcinoma cells (line Du-145) have been selected, and the effect of sodium selenite on the expression of mRNA of the SELV, SELW, and TGR selenocysteine proteins in these cells has been analyzed. PMID: 29989584
2. SelW may have a regulatory function in redox cell signaling by interacting with 14-3-3 protein. PMID: 26474786
3. Suppression of EGFR ubiquitination by SEPW1 may be related to the putative increase in cancer risk associated with high selenium intakes. PMID: 25721765
4. In response to selenium compounds, SepW1 synthesis increased at the protein and the mRNA levels. PMID: 23830627
5. p53 was increased in SEPW1 silenced cells and was inversely correlated with SEPW1 mRNA in cell lines with altered SEPW1 expression. PMID: 21866568
6. The present work shows that SEPW1 facilitates the G1 to S-phase transition by down-regulating expression of the cyclin-dependent kinase inhibitor p21 PMID: 21875573
7. The gene lacks canonical TATA and CAAT boxes, but has numerous Sp1 consensus binding sites upstream of multiple transcription start sites. SEPW1 is expressed in all of the 22 tissues assayed, and shows highest expression in skeletal muscle and heart. PMID: 12818432
8. SelW expression in the colon is highly sensitive to Se-depletion PMID: 15670848
9. SeW is the novel molecular target of MeHg in human neuronal cells and down-regulation of this selenoenzyme by MeHg is dependent not on generation of ROS but on depletion of GSH. PMID: 15823556
10. SEPW1 mRNA levels were maximal during G1-phase, dropped after the G1/S transition and increased again after G2/M-phase. PMID: 19387567
11. The small interfering RNA knockdown of BNIP3, IER3, and SEPW1 genes affected critical multiple myeloma endothelial cell functions correlated with the overangiogenic phenotype PMID: 19690192

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HGNC: 10752

OMIM: 603235

KEGG: hsa:6415

STRING: 9606.ENSP00000422644

UniGene: Hs.631549