SERTAD1 Antibody, Biotin conjugated

1. Here, the authors show that transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1, Sertad1), a newly identified protein with poorly characterized functions, acts as an adaptor that bridges the interaction of multiple Adenylyl cyclase isoforms with X-linked inhibitor of apoptosis protein (XIAP), a RING-domain E3 ubiquitin ligase. PMID: 28656888
2. NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1. Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 are identified by NMR titration experiments. PMID: 28666866
3. SEI1 up-regulation induces genomic instability by inhibiting DNA damage response in ovarian cancer cells. PMID: 27697611
4. Findings provide evidence that TRIP-Br1 functions as an oncogenic protein by providing cancer cells resistance to the hypoxia-induced cell death of breast cancer cells. PMID: 27035851
5. TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production. PMID: 26334958
6. Data demonstrate that p34SEI-1 induces the activation of either AKT or ILK signaling on HER2/neu expression status. PMID: 24789658
7. High SERTAD1 expression is associated with breast cancer. PMID: 23970032
8. These results suggest that p34 (SEI-1) inhibits ROS-induced cell death through by indirectly inducing ubiquitination of ASK1. PMID: 21725208
9. study shows that the p34SE1-1 expression level was not changed after H2O2 treatment at either protein or transcriptional levels PMID: 21344158
10. Translocation of small amount of NM23H1 into the nucleus induced by the overexpressions of SEI1/SET could increase the frequency of sister chromatid exchangein esophageal cancers. PMID: 20570897
11. p34SEI-1 strongly suppressed CREB-mediated transcription, and this suppression was overcome by excess amount of CBP PMID: 12736710
12. interacts with low- and high-risk HPV11 and HPV16 E6 proteins in yeast, in vitro and in mammalian cell cultures PMID: 14675634
13. p34SEI1 fragment 30-160 can bind, activate, and inhibit cyclin-dependent kinase CDK4; fragment 30-132 binds and activates but does not inhibit CDK4, while fragment 30-88 cannot bind, activate, or inhibit but retains LexA-mediated transactivation activity. PMID: 15065884
14. p34(SEI-1) and p16(INK4A) have different roles in development of squamous cell carcinoma of the head and neck PMID: 16201750

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HGNC: 17932

OMIM: 617850

KEGG: hsa:29950

STRING: 9606.ENSP00000350633

UniGene: Hs.269898