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SGK2 Antibody

Datasheet
Code CSB-PA193703
Size US$166
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Image
  • Immunohistochemistry (IHC) - SGK2 Antibody
    The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA193703(SGK2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Western Blotting(WB) - SGK2 Antibody
    Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human placenta tissue, Human fetal liver tissue, HepG2 cells, Primary antibody: CSB-PA193703(SGK2 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 8 minutes
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Product Details

Uniprot No.
Q9HBY8
Target Names
SGK2
Alternative Names
SGK2 antibody; Serine/threonine-protein kinase Sgk2 antibody; EC 2.7.11.1 antibody; Serum/glucocorticoid-regulated kinase 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide of Human SGK2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:25-1:100
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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SGK2 Proteins

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Target Background

Function
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
Gene References into Functions
  1. Loss of the paternally derived allele of the imprinted SGK2 gene is associated with Shwachman-Diamond syndrome. PMID: 27553422
  2. These findings suggest that SGK2 promotes hepatocellular carcinoma progression and mediates glycogen synthase kinase 3 beta/beta-catenin signaling in hepatocellular carcinoma cells. PMID: 28639896
  3. SGK2 stimulated hOAT4 transport activity by abrogating the inhibitory effect of Nedd4-2 on the transporter. PMID: 26740304
  4. Activation of hepatocyte pregnane X receptor is mediated through serum- and glucocorticoid-regulated kinase (SGK)2. PMID: 24204015
  5. Glucocorticoid inducible kinase isoforms SGK1-3 are novel potent stimulators of Slc6a19 and may thus participate in the regulation of neutral amino acid transport in vivo. PMID: 20511718
  6. Powerful stimulating effect of all three isoforms of SGK on K(+) channels. Those effects may participate in regulation of epithelial transport, cell proliferation, and neuromuscular excitability. PMID: 12397388
  7. All three members of the SGK family of kinases SGK1-3 and protein kinase B stimulate the slowly activating K(+) channel KCNE1/KCNQ1. The kinases may thus participate in the regulation of KCNE1-dependent transport and excitability. PMID: 12634932
  8. Co-expression of SGK1, but not of SGK2 or SGK3, increased Kv 4.3/KChIP2b channel currents. PMID: 15578212

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Tissue Specificity
Highly expressed in liver, kidney and pancreas, and at lower levels in brain.
Database Links

HGNC: 13900

OMIM: 607589

KEGG: hsa:10110

STRING: 9606.ENSP00000340608

UniGene: Hs.300863

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Related pathways
PI3K-Akt signaling pathway FoxO signaling pathway
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