SEM1 Antibody, HRP conjugated

Code CSB-PA021263LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SEM1 Polyclonal antibody
Uniprot No.
Target Names
SEM1
Alternative Names
SEM1 antibody; C7orf76 antibody; DSS1 antibody; SHFDG1 antibody; SHFM1 antibody; 26S proteasome complex subunit SEM1 antibody; 26S proteasome complex subunit DSS1 antibody; Deleted in split hand/split foot protein 1 antibody; Split hand/foot deleted protein 1 antibody; Split hand/foot malformation type 1 protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
Gene References into Functions
  1. Promoter methylation plays a role in modulating DSS1 gene expression. Promoter hypomethylation is a frequent event in melanoma and squamous cell carcinoma and is closely linked to poor prognosis. PMID: 27825810
  2. DSS1 is a multifunctional and intrinsically disordered protein. (Review) PMID: 26944332
  3. three phenotypic subregions within the SHFM1 locus link both size and genomic position of the chromosomal aberrations to the clinical variability seen in SHFM1 patients PMID: 26839112
  4. SHFM1 confers cell cycle progression and resistance to p53 stabilizing drugs in gastric cancer cells. PMID: 25697906
  5. by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression PMID: 26145171
  6. Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times. PMID: 24289229
  7. Mutation screening of the SHFM1 gene in familial breast/ovarian cancer cases. PMID: 23371468
  8. DSS1 protein is critically involved in the maintenance of the transformed phenotype in cervical cancer cells, and that it might be a specific, robust and reliable marker for early detection, diagnosis and trea PMID: 23024267
  9. DSS1 has a role in homologous recombinational repair in human cells PMID: 20817001
  10. p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development. PMID: 20808887
  11. The DSS1 c.143G>A variant is associated with reduced DSS1 expression at RNA and protein levels and altered traffic of the DSS1 protein from the cytoplasm to the nucleus. These alterations could impair DSS1 function and may be implicated in skin cancer. PMID: 20220765
  12. 3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif PMID: 12228710
  13. DSS1, responsible for autism, was studied in a linkage disequilibrium model. PMID: 17406092
  14. DSS1 has been shown to interact with components of the 26S proteasome in Saccharomyces cerevisiae and in human tumour cells PMID: 17563742
  15. Data suggest that the R3IM motif of DSS1, in conjunction with the complexes of 19S RP and 20S core particle, regulates proteasome interaction through RPN3/S3 molecule, and utilizes a specific subset of poly-ubiquitinated p53 as a substrate. PMID: 18775730

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Subcellular Location
Nucleus.
Protein Families
DSS1/SEM1 family
Tissue Specificity
Expressed in limb bud, craniofacial primordia and skin.
Database Links

HGNC: 10845

OMIM: 601285

STRING: 9606.ENSP00000248566

UniGene: Hs.489201

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