SHROOM3 Antibody

Code CSB-PA844740LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA844740LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA844740LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SHROOM3 Polyclonal antibody
Uniprot No.
Target Names
SHROOM3
Alternative Names
APXL3 antibody; hShrmL antibody; MSTP013 antibody; Protein Shroom3 antibody; Shrm antibody; Shrm3 antibody; SHRM3_HUMAN antibody; ShrmL antibody; Shroom family member 3 antibody; Shroom-related protein antibody; shroom3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein Shroom3 protein (1309-1571AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SHROOM3 Antibody (Product code: CSB-PA844740LA01HU) is Non-conjugated. For SHROOM3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA844740LB01HU SHROOM3 Antibody, HRP conjugated ELISA
FITC CSB-PA844740LC01HU SHROOM3 Antibody, FITC conjugated
Biotin CSB-PA844740LD01HU SHROOM3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.
Gene References into Functions
  1. Two protein-truncating de novo mutations in two independent cases in SHROOM3 strongly implicates this protein in severe human neural tube defects. PMID: 25805808
  2. variants disrupting the actin-binding domain of SHROOM3 may cause podocyte effacement and impairment of the glomerular filtration barrier PMID: 25273069
  3. The SNP rs17319721 functions as a cis-acting expression quantitative trait locus of SHROOM3 that facilitates TGF-B1 signaling and contributes to allograft injury. PMID: 25437874
  4. RESULTS: rs1260326 in GCKR (beta=1.30, P = 3.23E-03), rs17319721 in SHROOM3 (beta = -1.28, P-value = 3.18E-03) and rs12917707 in UMOD (beta = 2.0, P-value = 8.84E-04) were significantly associated with baseline estimated GFR PMID: 23586973
  5. A recessive missense mutation in SHROOM3 is associated with heterotaxy syndrome. PMID: 21936905

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Subcellular Location
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein.
Protein Families
Shroom family
Database Links

HGNC: 30422

OMIM: 604570

KEGG: hsa:57619

STRING: 9606.ENSP00000296043

UniGene: Hs.683808

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