SKA2 Antibody, FITC conjugated

Code CSB-PA823890LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SKA2 Polyclonal antibody
Uniprot No.
Target Names
SKA2
Alternative Names
FAM33A antibody; Family with sequence similarity 33; member A antibody; FLJ12758 antibody; MGC110975 antibody; Protein FAM33A antibody; SKA 2 antibody; SKA2 antibody; SKA2_HUMAN antibody; Spindle and kinetochore associated complex subunit 2 antibody; Spindle and kinetochore associated protein 2 antibody; Spindle and kinetochore-associated protein 2 antibody; Spindle and KT (kinetochore) associated 2 antibody; Spindle and KT associated 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Spindle and kinetochore-associated protein 2 protein (1-121AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Gene References into Functions
  1. decreased neuronal cell SKA complex genes' expression levels affect neuronal cell viability and neurite development PMID: 29268205
  2. study shows that decreased gene and protein expression of SKA2 observed in the prefrontal cortex of suicide victims is specific to suicide, which was not observed in the brain of nonsuicidal patients. It also indicates reduced SKA2 expression in suicide is independent of psychiatric diagnosis, since it is observed in all diagnostic groups studied. PMID: 26902949
  3. Possible association between SKA2 expression in prefrontal cortex and MDD. PMID: 27030168
  4. Data show that HOTAIR might act as an endogenous 'sponge' of miR-141, thereby regulating the derepression of SKA2. PMID: 27121316
  5. The study adds evidence that CREB, a tumor oncogene, promotes renal cell carcinoma proliferation. It probably achieves this by increasing SKA2 expression PMID: 26824422
  6. Kinetochores mature through Ska1/ska2/Ska3 complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint. PMID: 28495837
  7. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
  8. these data establish the importance of SKA2 for cortisol stress responsivity and the development of post-traumatic stress disorder and provide further evidence that SKA2 is a promising biomarker for stress-related disorders including PTSD. PMID: 26361058
  9. Results suggest that DNA methylation(adj) of SKA2 in blood indexes stress-related psychiatric phenotypes and neurobiology, pointing to its potential value as a biomarker of stress exposure and susceptibility. PMID: 26324104
  10. DNA methylation of the SKA2 gene has been implicated as a biomarker of suicide risk and posttraumatic stress disorder. PMID: 27038412
  11. SKA2 is hypothesized to reduce the ability to suppress cortisol following stress. PMID: 26305478
  12. PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells PMID: 26162986
  13. SKA2 significantly interacted with anxiety and stress to explain about 80% of suicidal behavior and progression from suicidal ideation to suicide attempt.SKA2 is a novel genetic and epigenetic marker involved in the etiology of suicide, suicidal behaviors PMID: 25073599
  14. The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1, Ska2, and Ska3. PMID: 22483620
  15. Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments. PMID: 22371557
  16. blocking of miR-301 in A549 cells leads to a decrease in the expression of the host gene, ska2. PMID: 20470754
  17. These data suggest that the Ska1/Ska2 complex plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing. PMID: 17093495
  18. Study discovered that FAM33A is protein partners for GRs and is involved in cell proliferation and GC signalling. PMID: 18583474

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Subcellular Location
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Protein Families
SKA2 family
Database Links

HGNC: 28006

OMIM: 616674

KEGG: hsa:348235

STRING: 9606.ENSP00000333433

UniGene: Hs.463607

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