SLA Antibody, FITC conjugated

Datasheet

Code	CSB-PA613387LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLA Polyclonal antibody

Uniprot No.

Q13239

Target Names

SLA

Alternative Names

hSLAP antibody; SLA 1 antibody; sla antibody; SLA1 antibody; SLAP 1 antibody; SLAP antibody; SLAP-1 antibody; SLAP1 antibody; SLAP1_HUMAN antibody; Src like adapter antibody; Src like adapter protein 1 antibody; Src like adaptor antibody; SRC-like-adapter antibody; Src-like-adapter protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Src-like-adapter protein (2-276AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Gene References into Functions

results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases PMID: 25800872
Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit bypasses the normal cellular negative feedback control PMID: 24284075
upon ligand stimulation SLAP stably associates with Flt3 through multiple phosphotyrosine residues in Flt3. SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3-ITD mutation PMID: 23300935
These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling. PMID: 22798681
Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids. PMID: 19631983
The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution. PMID: 16521218

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Subcellular Location

Cytoplasm. Endosome.

Tissue Specificity

Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.

Database Links

HGNC: 10902

OMIM: 601099

KEGG: hsa:6503

STRING: 9606.ENSP00000394049

UniGene: Hs.75367

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