SLC12A7 Antibody, Biotin conjugated

1. SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis. PMID: 26454676
2. Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 water channel, revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly. PMID: 21760919
3. analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4 PMID: 20516068
4. KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state. PMID: 18984587
5. In the metastatic cancer tissues, KCC4 colocalizes with IGF-I or EGF. PMID: 19887603
6. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown. PMID: 11976689

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HGNC: 10915

OMIM: 604879

KEGG: hsa:10723

STRING: 9606.ENSP00000264930

UniGene: Hs.172613