SLC15A2 Antibody

Code CSB-PA262561
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA262561(SLC15A2 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
SLC15A2
Alternative Names
FLJ33407 antibody; Hydrogen ion/peptide cotransporter; kidney antibody; Kidney H(+)/peptide cotransporter antibody; kidney isoform antibody; Oligopeptide transporter antibody; Oligopeptide transporter kidney isoform antibody; PEPT2 antibody; Peptide transporter 2 antibody; S15A2_HUMAN antibody; Slc15a2 antibody; Solute carrier family 15 (H+/peptide transporter) member 2 antibody; solute carrier family 15 (oligopeptide transporter); member 2 antibody; Solute carrier family 15 member 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human SLC15A2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports the dipeptide-like aminopeptidase inhibitor bestatin. Can also transport the aminocephalosporin antibiotic cefadroxil. Also able to transport carnosine. Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand.
Gene References into Functions
  1. PEPT2 is expressed in keratinocytes and involved in skin oligopeptide uptake. PMID: 27216463
  2. PEPT2 is functionally expressed in H441 cells, making the cell line a good in vitro model to study PEPT2 function and its regulation in human distal lung. PMID: 26168863
  3. In vitro study displayed different response to sorafenib depending on the genotype of SLC15A2. PMID: 25965825
  4. This study showed that ALAD2 and hPEPT2*2 may be valuable markers of risk, and indicate novel mechanisms of lead-induced neurotoxicity PMID: 25514583
  5. LNCaP expresses high levels of PEPT2 and PHT1. PMID: 22950754
  6. ALAD2 and hPEPT2*2 polymorphisms may exaggerate Pb blood burden in boys. PMID: 21327641
  7. PepT2-mRNA is expressed in U373-MG and glial cells but showed no regulation of PepT2-mRNA expression in both cell types. PMID: 20868728
  8. Data identify Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated transporters. PMID: 20406817
  9. anserine is recognized by the proton-coupled peptide transporters PEPT1 and PEPT2 with medium affinity. Anserine is able to displace other substrates from the transport process. PMID: 20067523
  10. Higher blood lead burden in children with the PEPT2*2 mutation may suggest that this common genetic variant is a biomarker of increased vulnerability to the neurotoxic effects of lowest level lead exposure. PMID: 19723536
  11. expression, localization and functional aspects of this protein in the normal respiratory tract and in cystic fibrosis PMID: 12579467
  12. Amino acid substitution at Arg57 in PEPT2 causes a complete loss of transport function. PMID: 15020234
  13. polymorphisms in the gene encoding hPEPT2 can alter substrate transport and therefore could affect drug disposition in vivo PMID: 15282265
  14. expression and function of the peptide transporter PepT2 (SLC15A2) in differentiated primary cultures of upper airway lung epithelia PMID: 15626774
  15. PEPT2-PDZK1 interaction thus plays a physiologically important role in both oligopeptide handling as well as peptide-like drug transport in the human kidney PMID: 16738539
  16. does not operate as a cotransporter in tissues where there is little or no pH gradient, such as choroid plexus, lung, or mammary gland PMID: 18367661
  17. PEPT2 plays a vital role in microbial recognition by nucleotide-binding oligomerization domain (NOD)-like receptor proteins PMID: 18474668
  18. PEPT2 to be the dominant transporter for the reabsorption of di- and tripeptides and its pharmacological substrates in the organism, and for the removal of these substrates from the cerebrospinal fluid PMID: 18668438
  19. the expression/activity of PEPT2 may be a critical factor in the modulation of opioidergic neurotransmission in vivo. PMID: 18762712
  20. PEPT2 polymorphism distributions differ significantly between Chinese, Malay and Asian Indian populations. Cephalexin pharmacokinetics were not different between Chinese and Asian Indians. PMID: 18766334
  21. hPEPT1 and hPEPT2 are unlikely to contribute to clinically important drug interactions in humans. PMID: 19246733

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
PTR2/POT transporter (TC 2.A.17) family
Tissue Specificity
Expressed in kidney. Not detected in intestine.
Database Links

HGNC: 10921

OMIM: 602339

KEGG: hsa:6565

STRING: 9606.ENSP00000417085

UniGene: Hs.518089

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