SLC22A8 Antibody

Code CSB-PA967057
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA967057(SLC22A8 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA967057(SLC22A8 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
SLC22A8
Alternative Names
hOAT3 antibody; OAT3 antibody; Organic anion transporter 3 antibody; S22A8_HUMAN antibody; SLC22A8 antibody; Solute carrier family 22 (organic anion transporter); member 8 antibody; Solute carrier family 22 member 8 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human SLC22A8
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene References into Functions
  1. Sgk1 stimulated OAT3 transport activity by interfering with the inhibitory effect of Nedd4-2 on the transporter. This study provides important insights into how OAT3-mediated drug elimination is regulated in vivo. PMID: 28608480
  2. SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort. PMID: 28371506
  3. The putative promoter sequences from hOAT1 (SLC22A6) and hOAT3 (SCL22A8) were cloned into a reporter plasmid. PMID: 26277839
  4. PPIs inhibit [(3)H]MTX transport via hOAT3 inhibition. PMID: 25239859
  5. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter. PMID: 25477469
  6. Pemetrexed is a superior substrate to methotrexate for hOAT3. PMID: 24042472
  7. In HEK293-Flp-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01]. PMID: 23649425
  8. High urine OAT1, OAT3 and OAT4 is associated with severe acute kidney injury. PMID: 21945944
  9. The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 PMID: 21865262
  10. Interaction of human OAT3 with 2,3-dimercapto-1-propanesulfonic acid (DMPS) determines the effect of human OAT3 on basolateral DMPS uptake in rabbit renal proximal tubules. PMID: 20237588
  11. Angiotensin II inhibited hOAT3 activity through the activation of PKCalpha, which led to an acceleration of hOAT3 endocytosis. PMID: 19878671
  12. polymorphisms in the OAT3 gene did not appear to be associated with changes in renal and tubular secretory clearance of pravastatin PMID: 12811365
  13. OAT3 plays an important role for anionic drug secretion in patients with renal diseases; expression levels of drug transporters such as OAT3 may be related to the alteration of renal drug secretion. PMID: 14984259
  14. data suggest that genetic variation in OAT3 may contribute to variation in the disposition of drugs PMID: 16291576
  15. These results indicate that the tissue-specific expression of hOAT3 might be regulated by the concerted effect of genetic (HNF1alpha and HNF1beta) and epigenetic (DNA methylation) factors. PMID: 16793932
  16. urinary excretion of topotecan hydroxyl acid is accounted for by transport via OAT3, as well as glomerular filtration, in both rats and humans PMID: 17556638
  17. Inhibition of renal uptake (via OAT3) and efflux processes (via MRP2 and MRP4) explains the possible sites of drug-drug interaction for methotrexate with probenecid and some NSAIDs, including their glucuronides. PMID: 17578901
  18. hOAT3 contributes to the renal uptake of rosuvastatin PMID: 17585018
  19. The five regulatory single nucleotide polymorphism(SNP)s of OAT3 identified in nephrectomized patients are unlikely to influence OAT3 mRNA expression or promoter activity. PMID: 18414781

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Subcellular Location
Basolateral cell membrane; Multi-pass membrane protein.
Protein Families
Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
Tissue Specificity
Expressed in kidney.
Database Links

HGNC: 10972

OMIM: 607581

KEGG: hsa:9376

STRING: 9606.ENSP00000337335

UniGene: Hs.266223

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