SLC26A9 Antibody

Code CSB-PA741974LA01HU
Size US$166
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Image
  • IHC image of CSB-PA741974LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA741974LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC26A9 Polyclonal antibody
Uniprot No.
Target Names
SLC26A9
Alternative Names
SLC26A9 antibody; Solute carrier family 26 member 9 antibody; Anion transporter/exchanger protein 9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Solute carrier family 26 member 9 protein (551-660AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SLC26A9 Antibody (Product code: CSB-PA741974LA01HU) is Non-conjugated. For SLC26A9 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA741974LB01HU SLC26A9 Antibody, HRP conjugated ELISA
FITC CSB-PA741974LC01HU SLC26A9 Antibody, FITC conjugated
Biotin CSB-PA741974LD01HU SLC26A9 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane.
Gene References into Functions
  1. Treatment response to ivacaftor, which aims to improve CFTR-channel opening probability in cystic fibrosis patients with gating mutations, shows substantial variability in response, 28% of which can be explained by rs7512462 in SLC26A9. PMID: 28171547
  2. when SLC26A9 is coexpressed with F508del CFTR, its trafficking defect leads to a PDZ motif-sensitive intracellular retention of SLC26A9. PMID: 28360110
  3. SLC26A9 single nucleotide polymorphisms modify prenatal exocrine pancreatic damage in cystic fibrosis PMID: 25771386
  4. We have identified two SLC26A9 mutations decreasing Cl- channel transport in patients with a CF-like lung disease. PMID: 24272871
  5. SLC26A9 is an epithelial chloride/bicarbonate channel that can interact with the CF transmembrane regulator (CFTR), the protein mutated in CF PMID: 23670970
  6. Several SNPs in the 3' UTR of SLC26A9 (rs12031234, rs2282429, rs2282430)were associated with asthma in children with asthma. PMID: 22945630
  7. SLC26A9 polymorphisms lead to several function modifications (increased activity, decreased activity, altered protein expression), which could lead to a spectrum of pathophysiologies. PMID: 22544634
  8. Single nucleotide polymorphism in SLC26A9 gene is associated with cystic fibrosis. PMID: 22466613
  9. Report functional interaction between CFTR and SLC26A9 in polarized airway epithelial cells and in non-polarized HEK293 cells. PMID: 21809345
  10. the L683P mutation of SLC26A9 was found to reduce Cl(-) transport through SLC26A9 as well as the positive interaction exerted by SLC26A9 on CFTR ion transport activity PMID: 21439353
  11. The interactions between SLC26A9 and CFTR were studied, and an alternative hypothesis to their known interactions is presented. PMID: 20658517
  12. Functions as an anion conductance in the apical membranes of bronchial epithelium; contributes to transepithelial chloride currents under basal and cyclic AMP/protein kinase A-stimulated conditions. PMID: 19289574
  13. Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport. PMID: 17120765
  14. SLC26A9 is a highly selective Cl(-) channel with minimal OH(-)/HCO(3)(-) permeability that is regulated by the WNK kinases. PMID: 17673510
  15. The transport properties of human SLC26A9 was studied to determine its functional and pharmacological characteristics. PMID: 18769029
  16. These results imply that Slc26-STAS domains may all interact with (R)CFTR but that the physiological outcome is specific to differing Slc26 proteins, allowing for dynamic and acute fine tuning of ion transport for various epithelia. PMID: 19643730

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
SLC26A/SulP transporter (TC 2.A.53) family
Tissue Specificity
Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.
Database Links

HGNC: 14469

OMIM: 608481

KEGG: hsa:115019

STRING: 9606.ENSP00000341682

UniGene: Hs.164073

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