SLC35C1 Antibody

1. two Turkish siblings with a novel mutation in GDP-fucose transporter and features of congenital disorder of glycosylation IIc PMID: 25239688
2. Fx enzyme and GDP-L-Fuc Tr overexpression in the tumur tissue of colorectal cancer (CRC) patients suggests that GDP-L-Fuc transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC. PMID: 23730929
3. In the rare LAD-II disease, the fucosylation of selectin ligands is disturbed, caused by mutations in SLC35C1, the gene that encodes a GDP-fucose transporter of the Golgi system. (Review) PMID: 22134107
4. the conserved glycine residues at positions 180 and 277 of SLC35C1 have significant impacts on lectin binding PMID: 22492235
5. In the GDP-fucose transporter a new single nucleotide deletion produced an open-reading frame shift & polypeptide truncation. Overexpression of the mutant protein in fibroblasts did not rescue fucosylation. The deletion ablated transporter activity. PMID: 12406889
6. Leukocyte adhesion deficiency II patients display dual defect in functoin ang Golgi expression of FUCT1. PMID: 16455955
7. the upregulation of GDP-Fuc Tr plays a pivotal role in increased fucosylation in hepatocellular carcinoma PMID: 17884843

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HGNC: 20197

OMIM: 266265

KEGG: hsa:55343

STRING: 9606.ENSP00000313318

UniGene: Hs.12211