SLC4A7 Antibody

1. rs3278 and rs3755652 stimulate an alternative transcription of the SLC4A7 gene, increasing the production of a defective transporter. PMID: 28087757
2. the disease-associated T allele of a new hypertension risk variant rs820430 linked increased hypertension risk through higher SLC4A7 expression, and rs820430 functioned as an enhancer of SLC4A7 transcription by allele distinctively increased c-Fos transcription factor binding. PMID: 27784683
3. this is the first work to demonstrate 3'UTR-mediated NBCn1 regulation, shows that p95HER2 regulates NBCn1 expression at multiple levels, and substantiates the central position of p95HER2-NBCn1 signaling in breast cancer. PMID: 27609814
4. The finding of a genotypic influence on SLC4A7 expression and pHi regulation in vascular smooth muscle cells provides an insight into the molecular mechanism underlying the association of variation at the SLC4A7 locus with blood pressure PMID: 28087731
5. Upregulation of NBCn1 during human breast carcinogenesis contributes to the characteristic acid distribution within human breast carcinomas. PMID: 24788003
6. A meta-analysis of genome-wide association studies of blood pressure and hypertension in Chinese identified three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. PMID: 25249183
7. We demonstrate, for the first time, that 3 different pHi regulators responsible for acid extruding, i.e. NHE and NBC, and MCT, are functionally co-existed in cultured radial artery smooth muscle cells. PMID: 25241983
8. The SLC4A7 variant rs4973768 is associated with breast cancer risk. PMID: 23117855
9. Na(+),HCO(3)(-)-cotransport is a major determinant of pH(i) in breast cancer. PMID: 22907202
10. Data show that DeltaNErbB2 expression elicited Na(+), HCO(3)(-) cotransporter NBCn1 upregulation, Ser(703)-phosphorylation of Na(+)/H(+) exchanger NHE1. PMID: 22120673
11. The present study generated a series of chimeras of human NBCe1-A and human NBCn1-A (SLC4A7). Replacing the fourth extracellular loop (EL4) of human NBCe1-A with EL4 of NBCn1-A creates an electroneutral NBC. PMID: 21224233
12. NBCn1 inhibition attenuated cathepsin release and had no net effect on viability of MCF7 cells. PMID: 20542029
13. The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the bicarbonate salvage trransporter isoform 3 PMID: 12403779
14. structural and functional study PMID: 14578046
15. NBC3 and CAII interact to maximize the HCO(3)(-) transport rate. Although PKA decreased NBC3 transport activity, it did so independently of the NBC3/CAII interaction and did not involve phosphorylation of NBC3Ct. PMID: 14736710
16. Results suggest that SLC4A7 allelic variants might alter dispositions and/or excretion of drugs and neurotransmitters in brain and periphery in ways that could contribute to differential vulnerabilities to addictions. PMID: 17624982

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HGNC: 11033

OMIM: 603353

KEGG: hsa:9497

STRING: 9606.ENSP00000295736

UniGene: Hs.250072