SLCO2A1 Antibody, Biotin conjugated

1. The findings reported here support causality of this SLCO2A1 mutation for autosomal recessive ICNC in this consanguineous Pakistani kindred. PMID: 27681482
2. In Japanese patients with chronic nonspecific multiple ulcers of the small intestine, 2 of the 4 patients had mutation in the SLCO2A1 gene, became resistant to medical therapy, and underwent strictureplasty or ileal resection after long-term follow-up. PMID: 27467110
3. in individuals carrying the SLCO2A1 A396T variant, the combination of thiazide-specific effects on free water generation and the increase in collecting duct water permeability from reduced SLCO2A1 activity combine to produce thiazide-induced hyponatremia PMID: 28783044
4. A novel missense mutation c.101T > C in the SLCO2A1 gene causes pachydermoperiostosis of the complete type. PMID: 28602931
5. Mutation analysis revealed a novel heterozygous mutation in the solute carrier organic anion transporter family member 2A1 gene at nucleotide 302 causing a substitution of the amino acid isoleucine to serine at codon 101 (p.IIe101Ser) in affected individuals. PMID: 27134495
6. We herein report patients with pachydermoperiostosis (PDP)due to SLCO2A1 mutation in a Korean family. Similar to other East Asian populations, the SLCO2A1 gene may be a possible mutation spot of PDP in the Korean population. PMID: 25810087
7. Data show that prostaglandin E3 (PGE3) uptake by prostaglandin transporter OATP2A1-expressing HEK293 cells (HEK/2A1) was the highest and followed by SLCO2B1 (HEK/1B1). PMID: 26692285
8. In this article we describe a novel mutation in the SLCO2A1 causing Pachydermoperiostosis in a Lebanese family PMID: 25059581
9. overexpression of SLCO2A1 could induce and knockdown inhibit the invasion of lung cancer cells. expression levels of p-mTOR, p-AKT and p-S6 were up-regulated or down-regulated with the overexpression or knockdown of SLCO2A1. PMID: 26464663
10. cytoplasmic OATP2A1 likely facilitates prostaglandin E2 loading into suitable intracellular compartment(s) for efficient exocytotic prostaglandin E2 release from colorectal cancer cells exposed to oxidative stress PMID: 26850138
11. findings indicate that loss-of-function mutations in the SLCO2A1 gene encoding a prostaglandin transporter cause the hereditary enteropathy CNSU PMID: 26539716
12. SLCO2A1 and NOS3 are involved with prostaglandin reuptake/metabolism and nitric oxide production, respectively, and are consistently decreased in "non-Caucasian" fetal ductus arteriosus PMID: 26265282
13. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. PMID: 25433169
14. OATP2A1 also diminished the PGE2-mediated expression of interleukin-8 mRNA (IL-8) and hypoxia-inducible-factor 1alpha (HIF1alpha) protein in AGS-OATP2A1 cells. PMID: 25433165
15. SLCO2A1 has a role in familial digital clubbing, colon neoplasia, and NSAID resistance PMID: 24838973
16. a novel nonsense mutation p.E141* of the SLCO2A1 gene is associated with pachydermoperiostosis PMID: 24929850
17. Three novel mutations within the SLCO2A1 gene have been demonstrated to be associated with Chinese primary hypertrophic osteoarthropathy patients. PMID: 24153155
18. Identified two novel mutations in SLCO2A1. PMID: 24185079
19. genetic association study in population in China: Nine different SLCO2A1 mutations were identified in subjects with primary hypertrophic osteoarthropathy (PHO) in 7 previously undescribed families; different homozygous mutations of SLCO2A1 cause PHO. PMID: 23509104
20. Report SLCO2A1 is a novel gene responsible for pachydermoperiostosis in Japanese patients. PMID: 22906430
21. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. PMID: 22696055
22. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. PMID: 22553128
23. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. PMID: 22331663
24. The findings confirmed that SLCO2A1 mutations inactivate prostaglandin E2 transport, and they indicated that mutations in SLCO2A1 are the pathogenic cause of primary hypertrophic osteoarthropathy. PMID: 22197487
25. expression in fetal membranesfound primarily in the choriodecidua PMID: 20357271
26. that PGT may play a role in transporting PGH(2) across cellular membranes. PMID: 20346915
27. Human endometrial stromal cells treated with a combination of cAMP and medroxyprogesterone acetate to induce decidualization showed an increase in protein and mRNA levels. PMID: 16339169
28. PGT level was significantly less in AD than in age-matched control brain homogenates. PMID: 18353443
29. The existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport. PMID: 19138942

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HGNC: 10955

OMIM: 601460

KEGG: hsa:6578

STRING: 9606.ENSP00000311291

UniGene: Hs.518270