SMG5 Antibody

Code CSB-PA021835GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SMG5
Alternative Names
SMG5 antibody; EST1B antibody; KIAA1089 antibody; Protein SMG5 antibody; EST1-like protein B antibody; LPTS-RP1 antibody; LPTS-interacting protein antibody; SMG-5 homolog antibody; hSMG-5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SMG5
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.
Gene References into Functions
  1. The authors found no evidence for the existence of a physical or functional interaction between SMG5 and PNRC2. PMID: 29348139
  2. This study highlights that miR-433 represses nonsense mediated mRNA decay. The miR-433 targets 3'-UTR of SMG5 and represses the expression of SMG5, whereas nonsense-mediated mRNA decay activity is decreased when SMG5 is decreased. PMID: 27473591
  3. Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5, and Smg7 led to increased levels of viral proteins and and virus release. PMID: 25211080
  4. Data show that phosphorylated hUPF1, the human ortholog of UPF1/SMG-2, forms a complex with human orthologs of the Caenorhabditis elegans proteins SMG-5 and SMG-7. PMID: 14636577
  5. HDAC8 regulation of hEST1B protein stability modulates total telomerase enzymatic activity PMID: 16809764

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Subcellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 24644

OMIM: 610962

KEGG: hsa:23381

STRING: 9606.ENSP00000355261

UniGene: Hs.516837

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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