SNF8 Antibody, FITC conjugated

Code CSB-PA856945LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SNF8 Polyclonal antibody
Uniprot No.
Target Names
SNF8
Alternative Names
Dot3 antibody; ELL associated protein of 30 kDa antibody; ELL-associated protein of 30 kDa antibody; ESCRT-II complex subunit VPS22 antibody; hVps22 antibody; snf8 antibody; SNF8 ESCRTII complex subunit homolog (S cerevisiae) antibody; SNF8_HUMAN antibody; Vacuolar sorting protein SNF8 antibody; Vacuolar-sorting protein SNF8 antibody; VPS22 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Vacuolar-sorting protein SNF8 protein (1-258AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan.
Gene References into Functions
  1. data describe an unappreciated role for EAP30 in IRF3-dependent innate antiviral response in the nucleus. PMID: 29084253
  2. Taken together, these data suggest an active role for ESCRT-II and CHMP6 in ESCRT-mediated abscission PMID: 25232011
  3. Modulating SNF8 expression levels alters the TRPC6 channel current and can modulate activation of NFAT-mediated transcription downstream of gain-of-function mutant TRPC6. PMID: 23171048
  4. mammalian ESCRTII is made up of hVps25p, hVps22p, and hVps36p and may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body PMID: 16371348
  5. there are probably multiple pathways for protein sorting/multivesicular body vesicle formation in human cells and that human immunodeficiency virus type 1 does not utilize an ESCRT-II-dependent pathway to leave the cell PMID: 16973552
  6. Vps22 has an important role in ligand-induced EGFR and CXCR4 turnover; termination of EGF signaling occurs prior to ESCRT-II engagement PMID: 17714434

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Subcellular Location
Cytoplasm. Endosome membrane. Nucleus. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.
Protein Families
SNF8 family
Database Links

HGNC: 17028

OMIM: 610904

KEGG: hsa:11267

STRING: 9606.ENSP00000421380

UniGene: Hs.127249

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