SNRK Antibody, Biotin conjugated

Code CSB-PA868301ND01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SNRK Polyclonal antibody
Uniprot No.
Target Names
SNRK
Alternative Names
DKFZp779A1866 antibody; FLJ20224 antibody; HSNFRK antibody; KIAA0096 antibody; SNF related kinase antibody; SNF related serine/threonine protein kinase antibody; SNF-related serine/threonine-protein kinase antibody; SNF1 related kinase antibody; SNF1-related kinase antibody; SNFRK antibody; Snrk antibody; SNRK_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human SNF-related serine/threonine-protein kinase protein (340-360AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
Gene References into Functions
  1. Study shows that TRIB3 binds to SNRK, and downregulates UCP3 through PPARalpha. SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner. PMID: 28117339
  2. Report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK and brain specific kinase (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK. PMID: 29061304
  3. SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart. PMID: 27780848
  4. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis. PMID: 28722495
  5. SNRK inhibits colon cancer cell proliferation through calcyclin-binding protein up-regulation and beta-catenin degradation, which results in reduced proliferation signaling. PMID: 22874833
  6. These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin signaling. PMID: 22874833
  7. SNRK could mediate some of the physiological effects of LKB1 PMID: 15733851

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Subcellular Location
Nucleus.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Tissue Specificity
Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.
Database Links

HGNC: 30598

OMIM: 612760

KEGG: hsa:54861

STRING: 9606.ENSP00000296088

UniGene: Hs.476052

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