SOX12 Antibody

Datasheet

Code	CSB-PA050122
Size	US$100
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Product Details
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Target Background

Product Details

Uniprot No.

O15370

Target Names

SOX12

Alternative Names

Homo sapiens SRY (sex determining region Y) box 12 antibody; Protein SOX-22 antibody; SOX 12 antibody; SOX 12 protein antibody; SOX 22 antibody; SOX 22 protein antibody; sox12 antibody; SOX12 protein antibody; SOX12_HUMAN antibody; SOX22 antibody; SOX22 protein antibody; SRY (sex determining region Y) box 12 antibody; SRY (sex determining region Y) box 22 antibody; SRY box 12 antibody; SRY box 22 antibody; SRY related HMG box gene 22 antibody; Transcription factor SOX 12 antibody; Transcription factor Sox-12 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human Sox-12.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:20000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3'. Acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions. Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation. Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.

Gene References into Functions

SOX12 can increase the expression of CDK4 and IGF2BP1, which confer malignant phenotypes to HepatocellularCarcinoma. PMID: 28975985
Data found that, in hepatocellular carcinoma (HCC) cell lines, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently compared to Sox12- HCC cells. Moreover, Sox12 appeared to functionally contribute to the stemness of HCC cells. PMID: 29127951
SOX12 may be involved in leukemia progression by regulating the expression of beta-catenin and then interfering with TCF/Wnt pathway, which may be a target for AML. PMID: 27858992
Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression. PMID: 25704764
This genome-wide screen has identified two novel metastatic suppressors: TMED3 and SOX12, the knockdown of which increases metastatic growth after direct seeding. PMID: 24920608
SOX12 and NRSN2 were identified as candidate genes that may be involved in the developmental defects in 20p13 microdeletion. PMID: 24019301
Functional analysis of the orthologous mouse gene. PMID: 185058

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Subcellular Location

Nucleus.

Tissue Specificity

Expressed most abundantly in the CNS. Expressed in the heart, pancreas, thymus, testis and ovary. Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes.

Database Links

HGNC: 11198

OMIM: 601947

KEGG: hsa:6666

UniGene: Hs.43627

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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