SOX30 Antibody, HRP conjugated

Code CSB-PA022430LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SOX30 Polyclonal antibody
Uniprot No.
Target Names
SOX30
Alternative Names
SOX30 antibody; Transcription factor SOX-30 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription factor SOX-30 protein (84-206AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as both a transcriptional activator and repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4.
Gene References into Functions
  1. these results highlight an important role and mechanism of SOX30 in lung cancer metastasis, providing a potential therapeutic target for anti-metastasis. PMID: 29739711
  2. SOX30 expression represents an important prognostic factor for survival time in lung adenocarcinoma patients. PMID: 26330328
  3. Blockade of p53 attenuates the tumor inhibition of SOX30. PMID: 25435374
Subcellular Location
Nucleus. Cytoplasm.
Database Links

HGNC: 30635

OMIM: 606698

KEGG: hsa:11063

STRING: 9606.ENSP00000265007

UniGene: Hs.529462

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