SPCS1 Antibody

Datasheet

Code	CSB-PA896543LA01HU
Size	US$166
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Image	Immunofluorescent analysis of MCF-7 cells using CSB-PA896543LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPCS1 Polyclonal antibody

Uniprot No.

Q9Y6A9

Target Names

SPCS1

Alternative Names

HSPC033 antibody; Microsomal signal peptidase 12 kDa subunit antibody; OTTHUMP00000206959 antibody; signal peptidase 12kDa antibody; Signal peptidase complex subunit 1 antibody; signal peptidase complex subunit 1 homolog (S. cerevisiae) antibody; SPase 12 kDa subunit antibody; SPC1 antibody; SPC12 antibody; SPCS1 antibody; SPCS1_HUMAN antibody; YJR010C-A antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Signal peptidase complex subunit 1 protein (70-102AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPCS1 Antibody (Product code: CSB-PA896543LA01HU) is Non-conjugated. For SPCS1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA896543LB01HU	SPCS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896543LC01HU	SPCS1 Antibody, FITC conjugated
Biotin	CSB-PA896543LD01HU	SPCS1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.; (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1. In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2.

Gene References into Functions

the results demonstrate that SPCS1 affects viral replication by interacting with NS2B, thereby influencing the posttranslational processing of Japanese Encephalitis Virus proteins and the assembly of virions. PMID: 29593046
SPCS1 plays a key role in the formation of the membrane-associated NS2-E2 complex via its interaction with NS2 and E2, which leads to a coordinating interaction between the structural and non-structural proteins PMID: 24009510

Subcellular Location

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

SPCS1 family

Database Links

HGNC: 23401

OMIM: 610358

KEGG: hsa:28972

STRING: 9606.ENSP00000233025

UniGene: Hs.11125

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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