ST14 Antibody

1. the data strongly advocate this ST14 variant as the underlying genetic cause of autosomal recessive ichthyosis with hypotrichosis syndrome in this first reported affected family from Pakistan. Moreover, the present study adds to the spectrum of mutations in the ST14 gene, implicating them in the pathogenesis of autosomal recessive ichthyosis with hypotrichosis syndrome. PMID: 29611532
2. limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase PMID: 29438412
3. Abrogation of matriptase expression by silencing with RNAi or inhibition of matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro-HGF to active HGF and subsequent c-Met-mediated signaling. PMID: 27528224
4. Data, including data from studies using cadaver tissue, suggest that matriptase and matriptase mRNA are expressed in several regions of the brain with an enrichment in neurons; higher levels of matriptase RNA are expressed in young individuals as compared to older individuals; matriptase cleaves amyloid beta precursor protein at a specific arginine residue (Arg-102). PMID: 29054928
5. Activation of proHGF by St14 induces mouse embryonic stem cell differentiation. PMID: 27316827
6. The authors report that ST14/Prss14 is an emerging therapeutic target for breast cancer where HER2 is not applicable. PMID: 27167193
7. These results identify EpCAM as a substrate of matriptase and link HAI-2, matriptase, EpCAM, and claudin-7 in a functionally important pathway that causes disease when it is dysregulated. PMID: 28094766
8. Matriptase is present in macrophages from patients with mutated alpha-1 antitrypsin at high levels and contributes to their proteolytic activity on extracellular matrix. MMP-14 is a novel substrate for matriptase, which regulates the levels of MMP-14 on the cell surface. High levels of matriptase may contribute to increased ECM degradation by Z-M, both directly and through MMP-14 activation. PMID: 28362108
9. Ultraviolet irradiation/reactive oxygen species induced matriptase proteolysis may have short term protective effects and contribute to the recovery from acute epidermal damage and/or pathology of skin with chronic sun damage. PMID: 26996264
10. Given that matriptase-1 participates in terminal KC differentiation, its absence in psoriatic skin lesions indicates that this contributes to the barrier disturbances in this disease. PMID: 26513078
11. Novel findings reveal a new paradigm in matriptase activation involving PDGF-D-specific signal transduction leading to extracellular acidosis. PMID: 26157007
12. Maritriptase is required for pro-HGF/c-Met signaling and cell proliferation in breast cancer cells. PMID: 25873032
13. Matriptase inhibition by HAI-2 requires the translocation of HAI-2 to the cell surface, a process which is observed in some breast cancer cells but not in mammary epithelial cells. PMID: 25786220
14. Report potent/specific inhibition of matriptase by the cyclic microprotein MCoTI-II. PMID: 24696092
15. Matriptase expression correlates with tumour progression and invasive capability in oral squamous cell carcinoma PMID: 24382204
16. Matriptase can act as a cellular sensor of the chemical environment of the cell that allows the cell to respond to and protect itself from changes in the chemical milieu. PMID: 24705933
17. It presents evidence that matriptase efficiently cleaves the HR1 portion of gp41 into a 22-residue chemotactic peptide MAT-1, the sequence of which is highly conserved across HIV-1 clades. PMID: 24617769
18. Dysregulated pericellular proteolysis as a result of unregulated matriptase expression with limited HAI-1 may contribute to the pathological characteristics of several human B-cell lymphomas. PMID: 24070417
19. Human matriptase may be involved in the regulation of keratinocyte growth and early differentiation, rather than terminal differentiation, providing mechanistic insights into the pathology of two congenital ichthyoses. PMID: 23900022
20. matriptase expression and zymogen activation in hair follicles PMID: 24004857
21. higher expression of matriptase is an independent prognostic factor involved in the progression of esophageal squamous cell carcinoma (ESCC). PMID: 24248283
22. High matriptase expression is associated with prostate cancer. PMID: 23466486
23. prostasin is a non-enzymatic co-factor for matriptase activation PMID: 23673661
24. Matriptase mRNA was detected in B-cell-derived Namalwa and Raji cells PMID: 23044656
25. Prostasin requires expression of endogenous matriptase to stimulate barrier formation since matriptase depletion by siRNA silencing abrogates prostasin barrier-forming activity. PMID: 23443662
26. Authors identify and characterize matriptase as an influenza virus-activating protease capable of supporting multicycle viral replication in the human respiratory epithelium. PMID: 23365447
27. H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity. PMID: 23192872
28. Emergent active matriptase is a functional biomarker of the transformed epithelium and that its proteolytic activity can be exploited to noninvasively evaluate tumorigenesis in vivo. PMID: 23248318
29. matriptase has the ability to cleave HA directly or indirectly by activating HA-cleaving zymogens PMID: 22811538
30. Dsg-2 with a mutation at the predicted cleavage site is resistant to cleavage by matriptase. Thus Dsg-2 seems to be a functionally relevant physiological substrate of matriptase. PMID: 22783993
31. Matriptase protein and ST14 mRNA levels are significantly downregulated in inflamed colonic tissues from Crohn's disease and ulcerative colitis PMID: 22081509
32. there is much more active prostasin than active matriptase on the apical and basolateral surfaces of airway epithelial cells PMID: 22582115
33. Matriptase protein expression was correlated with HER2 expression and highest expression was seen in HER2-positive cell lines, indicating a potential role in this subgroup. PMID: 22514623
34. Study provided the gene expression profile of HBV-related HCC and presented differential expression patterns of SATB-1, TM4SF-1 and ST-14 between cancerous and noncancerous tissues in patients with HBV-related HCC. PMID: 22088470
35. A reverse binding motif that contributes to specific protease inhibition by antibodies. PMID: 22154938
36. Expression of matriptase and prostasin is closely correlated in breast cancer cell lines and in breast cancer tissues. Matriptase and prostasin display a near identical spatial expression pattern in the epithelial compartment of breast cancer tissue. PMID: 21678412
37. matriptase as an initiator of c-Met-Akt-mTor-dependent signaling axis in tumors and mTor activation as an essential component of matriptase/c-Met-induced carcinogenesis PMID: 21217780
38. Although activated matriptase is not detected in normal epidermis, a dramatic increase is seen in keratinocytes at the site of inflammation in 16 different skin diseases. PMID: 21123732
39. Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase. PMID: 21148558
40. Epithin, which regulates endothelial Tie2 functions, plays a critical role in the fine tuning of transendothelial migration for normal and cancer cells. PMID: 21097670
41. ErbB-2 signaling via the phosphatidylinositol 3-kinase pathway results in up-regulated matriptase zymogen activity, which contributes to prostate cancer cell invasion. PMID: 20971737
42. The ST14 variant rs704624 and protein expression of matriptase have prognostic significance in breast cancer. PMID: 20716618
43. Soluble form of the protein secreted from cancer cells contains active angiogenic potential PMID: 20652801
44. Study unveiled a novel signaling axis of matriptase/PDGF-D/beta-PDGFR in PCa, providing new insights into functional interplay between serine protease and growth factor signaling networks. PMID: 21098708
45. matriptase is expressed in glioma cells and that matriptase specifically cleaves ASIC1 in heterologous expression systems. PMID: 20601429
46. results support a key role for matriptase in regulating intestinal epithelial barrier competence, and suggest an intriguing link between pericellular serine protease activity and tight junction assembly in polarized epithelia PMID: 20142489
47. MT-SP1 activity as a useful biomarker to visualize epithelial cancers using a noninvasive antibody-based method. PMID: 20145119
48. HGF is activated by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. PMID: 20015050
49. Matriptase activation is an early cellular response to acidosis PMID: 19940125
50. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase PMID: 11792696

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HGNC: 11344

OMIM: 602400

KEGG: hsa:6768

STRING: 9606.ENSP00000278742

UniGene: Hs.504315