Name: ST3GAL4 Antibody
Brand: CUSABIO
SKU: CSB-PA612121LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ST3GAL4 Polyclonal antibody

Uniprot No.

Q11206

Target Names

ST3GAL4

Alternative Names

ST3GAL4 antibody; CGS23 antibody; NANTA3 antibody; SIAT4C antibody; STZ antibody; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 antibody; Alpha 2,3-ST 4 antibody; Beta-galactoside alpha-2,3-sialyltransferase 4 antibody; EC 2.4.99.2 antibody; EC 2.4.99.4 antibody; Alpha 2,3-sialyltransferase IV antibody; Gal-NAc6S antibody; Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase antibody; SAT-3 antibody; ST-4 antibody; ST3Gal IV antibody; ST3GalIV antibody; ST3GalA.2 antibody; STZ antibody; Sialyltransferase 4C antibody; SIAT4-C antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 protein (39-184AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ST3GAL4 Antibody (Product code: CSB-PA612121LA01HU) is Non-conjugated. For ST3GAL4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA612121LB01HU	ST3GAL4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA612121LC01HU	ST3GAL4 Antibody, FITC conjugated
Biotin	CSB-PA612121LD01HU	ST3GAL4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage. Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets. Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation. Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2. In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively. Metabolizes brain c-series ganglioside GT1c forming GQ1c. Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin.

Gene References into Functions

The V1 transcript of the ST3GAL4 demonstrated significant decreased expression in premalignant and malignant cervical tissues. PMID: 29749491
study illustrates the power of next-generation sequencing in the discovery of new genetic variants and a significant ethnic diversity in the ST3GAL4 gene PMID: 27584569
ST3GAL IV affects apoptotic signal, cell proliferation and the effectiveness of imatinib treatment in chronic myeloid leukemia cells. PMID: 28512058
TNF-responsive element in an intronic region of the ST3GAL4 gene, whose TNF-dependent activity is repressed by ERK/p38 and MSK1/2 inhibitors. This TNF-responsive element contains potential binding sites for ETS1 and ATF2 transcription factors related to TNF signaling. PMID: 27821620
There may be a racial/ethnic-specific association, and/or sex-specific association between the ST3GAL4 rs11220462 SNP and serum lipid parameters in some ethnic groups. PMID: 25086711
The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions and cervical cancer. PMID: 24606438
the role of ST3Gal IV in the acquisition of adhesive, migratory and metastatic capabilities and, secondly, in analyzing the expression of ST3Gal III and ST3Gal IV in pancreatic adenocarcinoma tissues, was investigated. PMID: 23726834
The expression of ST3GAL4 leads to SLe(x) antigen expression in gastric cancer cells which in turn induces an increased invasive phenotype through the activation of c-Met PMID: 23799130
TNF increases the expression of alpha2,3-sialyltransferase gene ST3GAL4 PMID: 22691873
These data suggest that the ST3GAL4 gene is responsible for biosynthesis of the viral receptor and may play a crucial role in infection of H5N1 avian influenza virus in humans. PMID: 20383541
Expression of ST3Gal IV in several gastrointestinal cell lines is correlated with the expression of sialyl Lewis x at the cell surface. PMID: 19781661
down-regulation of ST3Gal IV mRNA may be one of the factors associated with the malignant progression of human renal cell carcinoma. PMID: 12375029
Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines. PMID: 12565846
IL-1 beta-induced sLeX expression on HuH-7 cells was suppressed by transfection of gene-specific small interference RNAs against FUT VI and ST3Gal IV but not against FUT IV and ST3Gal III. PMID: 17054948
Thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV(-/-) mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. PMID: 19520807

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Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Protein Families

Glycosyltransferase 29 family

Tissue Specificity

Highly expressed in adult placenta, heart and kidney.

Database Links

HGNC: 10864

OMIM: 104240

KEGG: hsa:6484

STRING: 9606.ENSP00000227495

UniGene: Hs.591947

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Code	CSB-PA612121LA01HU
Size	US$166
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Image	IHC image of CSB-PA612121LA01HU diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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ST3GAL4 Antibody

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Target Background