ST6GALNAC3 Antibody

Datasheet

Code	CSB-PA836724LA01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ST6GALNAC3 Polyclonal antibody

Uniprot No.

Q8NDV1

Target Names

ST6GALNAC3

Alternative Names

ST6GALNAC3 antibody; SIAT7C antibody; UNQ2787/PRO7177Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 antibody; EC 2.4.99.7 antibody; GalNAc alpha-2,6-sialyltransferase III antibody; ST6GalNAc III antibody; ST6GalNAcIII antibody; STY antibody; Sialyltransferase 7C antibody; SIAT7-C antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 protein (40-305AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ST6GALNAC3 Antibody (Product code: CSB-PA836724LA01HU) is Non-conjugated. For ST6GALNAC3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836724LB01HU	ST6GALNAC3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836724LC01HU	ST6GALNAC3 Antibody, FITC conjugated
Biotin	CSB-PA836724LD01HU	ST6GALNAC3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity.

Gene References into Functions

genome-wide association study in population in Finland: Data suggest that one SNP in ST6GALNAC3 (rs12144344) and two SNPs in VDBP (vitamin D binding protein; rs7041, rs705117) are associated with serum levels of VDBP in the male population studied. PMID: 24740207
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20421487
Results describe the molecular cloning and expression of human ST6GalNAc III, including its tissue distribution and substrate specificity. PMID: 16169874
Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826

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Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyltransferase 29 family

Tissue Specificity

Expressed in brain and kidney. Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules.

Database Links

HGNC: 19343

OMIM: 610133

KEGG: hsa:256435

STRING: 9606.ENSP00000329214

UniGene: Hs.337040

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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