STAB2 Antibody

1. Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor. PMID: 29589907
2. Data show that the hyaluronan receptor for endocytosis (HARE) NPLY2519 motif is necessary for both extracellular signal-regulated kinases ERK1/2 and NF-kappa B (NF-kappaB)signaling and that Tyr2519 is critical for these functions. PMID: 27100626
3. Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors PMID: 27919991
4. HARE/Stabilin-2 splice variants are expressed in bone marrow, lymph node, and spleen PMID: 25446080
5. a Link domain complex N-glycan is required specifically for HARE.hyaluronic acid-mediated activation of ERK1/2 and NF-kappaB-mediated gene expression PMID: 24942734
6. Loss of Stabilin-2 expression in peri-tumourous transdifferentiated liver endothelial cells correlates with increased survival by preventing endothelial-tumour cell adhesive interactions and microvascular invasion. PMID: 23870052
7. HARE may be part of a systemic tissue-stress sensor feedback system that responds to abnormal tissue turnover or damage as a danger signal PMID: 24247245
8. stabilin-2 acts as a receptor for necrotic cell clearance. PMID: 23416077
9. Hyaluronan binding to HARE mediates NF-kappaB-activated gene expression in a dose-dependent manner. PMID: 23530033
10. knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors PMID: 22566688
11. Ligament Flavum (LF) hypertrophy is accompanied by increased CD44 and CD44v5 expression. CD44v6 expression is not enhanced in LF hypertrophy. PMID: 22052472
12. The results indicate that Link domain N-glycans stabilize interactions that facilitate HA binding to HARE. PMID: 20466649
13. code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs PMID: 11829752
14. amino acid sequence of 190-kDa protein composed of 1416 amino acids and alignment with rat sequence PMID: 12626425
15. HARE has a role in endocytosis and species-specific glycosaminoglycan affinity PMID: 15208308
16. A majority of HARE isoform is intracellular, within the endocytic system, suggesting transient surface residency typical of an active endocytic recycling receptor. PMID: 17145755
17. study provides evidence that stabilin-2 is a novel phosphatidylserine receptor, which performs a key function in the rapid clearance of cell corpses PMID: 17962816
18. GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis PMID: 18230608
19. when HARE binds HA, that leads to activation of ERK1/2, important mediators of intracellular signal transduction. PMID: 18387958
20. HARE in the sinusoidal endothelial cells of lymph nodes and liver likely mediates the efficient systemic clearance of Hep and many different Hep-binding protein complexes from the lymphatic and vascular c PMID: 18434317
21. HARE binds to hyaluronan and heparin simultaneously PMID: 18499864
22. Thymosin beta4 is a downstream molecule of stabilin-2 that plays a role in stabilin-2-mediated cell corpse clearance. PMID: 18519035
23. although NPLY may be the most important motif, it functions together with two other endocytic motifs; thus three signal sequences (YSYFRI, FQHF, and NPLY) provide redundancy to mediate coated pit targeting and endocytosis of HARE PMID: 18539600
24. Epidermal growth factor (EGF)-like domain repeats (EGFrp) in stabilin-2 can directly and specifically recognize phosphatidylserine. PMID: 18573870
25. Both unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) are cleared by HARE/Stab2. The differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. PMID: 19359419

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HGNC: 18629

OMIM: 608561

KEGG: hsa:55576

STRING: 9606.ENSP00000373539

UniGene: Hs.408249