STX8 Antibody, FITC conjugated

1. Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes. PMID: 27094127
2. Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4. PMID: 25523146
3. Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability PMID: 25404741
4. Syntaxin-8 regulates the endocytosis of TASK-1. PMID: 24743596
5. These results suggest that STX8 mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney. PMID: 24659781
6. There are increases in CARB localized to intraneuronal neurofibrillary tangles and granulovacuolar degeneration in susceptible hippocampal and cortical neurons in Alzheimer's disease. PMID: 14991845
7. syntaxin 8 contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery PMID: 15039462
8. Has two functionally distinct di-leucine-based motifs that act independently in its endocytic and exocytic processes. PMID: 17965969
9. Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes. PMID: 18980942

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HGNC: 11443

OMIM: 604203

KEGG: hsa:9482

STRING: 9606.ENSP00000305255

UniGene: Hs.431109