STXBP3 Antibody

Datasheet

Code	CSB-PA022907ESR2HU
Size	US$166
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Image	Western blot All lanes: STXBP3 antibody at 10μg/ml Lane 1: HepG2 whole cell lysate Lane 2: K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 68 kDa Observed band size: 68 kDa Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA022907ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STXBP3 Polyclonal antibody

Uniprot No.

O00186

Target Names

STXBP3

Alternative Names

Munc18 3 antibody; Munc18 c antibody; Platelet Sec1 protein antibody; Protein unc-18 homolog 3 antibody; Protein unc-18 homolog C antibody; PSP antibody; STXB3_HUMAN antibody; STXBP 3 antibody; STXBP3 antibody; Sxtbp3 antibody; syntaxin 4 binding protein antibody; Syntaxin binding protein 3 antibody; Syntaxin-binding protein 3 antibody; Unc 18 3 antibody; Unc 18 homolog 3 antibody; Unc 18c antibody; Unc-18C antibody; Unc18-3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Syntaxin-binding protein 3 protein (343-592AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Gene References into Functions

PP2B-Aalpha-Munc18c complex supports agonist-induced VWF secretion by HUVECs. PMID: 28294518
Munc18c gene expression in human adipose tissue is down-regulated in morbid obesity. PMID: 23700440
Western Blot data showed decreased expression (p < 0,05) of Munc18c and phospho-PKC Zeta in polycystic ovary-insulin resistant endometria (PCOSE-IR) with respect to the control. PMID: 22390153
The identify IR as the first known tyrosine kinase for Munc18c as part of a new insulin-signaling step in GLUT4 vesicle exocytosis. PMID: 21444687
Calpha activation and phosphorylation of syntaxin 4 and Munc18c are required for the cell surface expression of P-selectin and the consequent binding of neutrophils to endothelial cells. PMID: 15576373
These results indicate that insulin induces dynamic associations between PKCzeta, 80K-H, and munc18c and that 80K-H may act as a key signaling link between PKCzeta and munc18c in live cells. PMID: 19061073

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Subcellular Location

Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.

Protein Families

STXBP/unc-18/SEC1 family

Tissue Specificity

Megakaryocytes and platelets.

Database Links

HGNC: 11446

OMIM: 608339

KEGG: hsa:6814

STRING: 9606.ENSP00000359025

UniGene: Hs.530436

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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