STXBP3 Antibody

Code CSB-PA022907ESR2HU
Size US$166
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  • Western blot
    All lanes: STXBP3 antibody at 10μg/ml
    Lane 1: HepG2 whole cell lysate
    Lane 2: K562 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 68 kDa
    Observed band size: 68 kDa

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA022907ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) STXBP3 Polyclonal antibody
Uniprot No.
Target Names
STXBP3
Alternative Names
Munc18 3 antibody; Munc18 c antibody; Platelet Sec1 protein antibody; Protein unc-18 homolog 3 antibody; Protein unc-18 homolog C antibody; PSP antibody; STXB3_HUMAN antibody; STXBP 3 antibody; STXBP3 antibody; Sxtbp3 antibody; syntaxin 4 binding protein antibody; Syntaxin binding protein 3 antibody; Syntaxin-binding protein 3 antibody; Unc 18 3 antibody; Unc 18 homolog 3 antibody; Unc 18c antibody; Unc-18C antibody; Unc18-3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Syntaxin-binding protein 3 protein (343-592AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
Gene References into Functions
  1. PP2B-Aalpha-Munc18c complex supports agonist-induced VWF secretion by HUVECs. PMID: 28294518
  2. Munc18c gene expression in human adipose tissue is down-regulated in morbid obesity. PMID: 23700440
  3. Western Blot data showed decreased expression (p < 0,05) of Munc18c and phospho-PKC Zeta in polycystic ovary-insulin resistant endometria (PCOSE-IR) with respect to the control. PMID: 22390153
  4. The identify IR as the first known tyrosine kinase for Munc18c as part of a new insulin-signaling step in GLUT4 vesicle exocytosis. PMID: 21444687
  5. Calpha activation and phosphorylation of syntaxin 4 and Munc18c are required for the cell surface expression of P-selectin and the consequent binding of neutrophils to endothelial cells. PMID: 15576373
  6. These results indicate that insulin induces dynamic associations between PKCzeta, 80K-H, and munc18c and that 80K-H may act as a key signaling link between PKCzeta and munc18c in live cells. PMID: 19061073

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Subcellular Location
Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.
Protein Families
STXBP/unc-18/SEC1 family
Tissue Specificity
Megakaryocytes and platelets.
Database Links

HGNC: 11446

OMIM: 608339

KEGG: hsa:6814

STRING: 9606.ENSP00000359025

UniGene: Hs.530436

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