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SUSD4 Antibody, HRP conjugated

Datasheet
Code CSB-PA733164LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SUSD4 Polyclonal antibody
Uniprot No.
Q5VX71
Target Names
SUSD4
Alternative Names
SUSD4 antibody; UNQ196/PRO222 antibody; Sushi domain-containing protein 4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sushi domain-containing protein 4 protein (56-290AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
Gene References into Functions
  1. SUSD4 expression in both breast cancer cells and T cells infiltrating the tumor-associated stroma is useful to predict better prognosis of breast cancer patients. PMID: 26480818
  2. Membrane-bound isoform SUSD4a inhibits the classical and alternative complement pathways when expressed on the surface of Chinese hamster cells but not when expressed as a soluble, truncated protein. PMID: 23482636
  3. analysis of cloning, expression, refolding, and tissue distribution of Sushi domain-containing protein 4 PMID: 20348246
Subcellular Location
[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
Tissue Specificity
Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain.
Database Links

HGNC: 25470

OMIM: 615827

KEGG: hsa:55061

UniGene: Hs.497841

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