SYNE2 Antibody

1. variants of EGFR and SYNE2 play an important role in p21 regulation and are associated with the clinical outcome of HBV-related hepatocellular carcinoma in a TP53-indenpdent manner PMID: 27502069
2. The authors identified the nuclear envelope protein nesprin-2 as a binding partner for fascin in a range of cell types in vitro and in vivo. Nesprin-2 interacts with fascin through a direct, F-actin-independent interaction, and this binding is distinct and separable from a role for fascin within filopodia at the cell periphery. PMID: 27554857
3. these data identify N-terminal nesprin-2 variants as novel regulators of beta-catenin signaling. PMID: 27321956
4. We show that AMPH-1/BIN1 binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies. PMID: 26506308
5. The significance of these shorter isoforms of nesprin, were evaluated. PMID: 24718612
6. nesprin-1 and nesprin-2 both regulate nuclear and cytoplasmic architecture. PMID: 24931616
7. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development. PMID: 25516977
8. Each mutation in LMNA has a distinct impact on the Nersprin-2 interaction that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases. PMID: 23977161
9. High Nesprin-2 expression is associated with colorectal cancer. PMID: 24080406
10. Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds. PMID: 22768332
11. Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex). PMID: 22632968
12. novel isoform, nesprin-2-epsilon, was found to be the major mRNA and protein product of the nesprin-2 gene. PMID: 21820406
13. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development PMID: 20108321
14. Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope. PMID: 20801886
15. Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. PMID: 19861416
16. Nesprin-2 binds lamin and emerin at the nuclear envelope in skeletal muscle. PMID: 15671068
17. Nesprin-2 has a scaffolding function at the nuclear membrane PMID: 15843432
18. The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1. PMID: 16079285
19. The characterisation of the residues both in emerin and in nesprin-1alpha and -2beta which are involved in their interaction is reported. PMID: 17462627
20. Screening for DNA variations in the genes encoding nesprin-1 (SYNE1) and nesprin-2 (SYNE2) in 190 probands with Emery Dreifuss muscular dystrophy identified four heterozygous missense mutations. PMID: 17761684
21. propose nesprin-2 giant as a structural reinforcer at the nuclear envelope in LMNA S143F progeria cells PMID: 17881656
22. Nesprin-2 is an important scaffold protein implicated in the maintenance of nuclear envelope architecture. PMID: 18477613
23. association with human nesprin-3 appeared to be stronger for torsinADeltaE than for torsinA. TorsinA also associated with the KASH domains of nesprin-1 and -2 PMID: 18827015

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HGNC: 17084

OMIM: 608442

KEGG: hsa:23224

STRING: 9606.ENSP00000350719

UniGene: Hs.745014