SYT11 Antibody

1. ATP13A2 and SYT11 form a functional network in the regulation of the autophagy-lysosome pathway, which may contribute to forms of Parkinson's Disease-associated neurodegeneration. PMID: 27278822
2. parkin deficiency induces synaptotagmin-11 accumulation and PD-like neurotoxicity in mouse models, which is reversed by SYT11 knockdown in the SNpc or knockout of SYT11 restricted to dopaminergic neuron PMID: 29311685
3. In summary, This study supports the existence of association between Parkinson disease and markers in or around SYT11 PMID: 26944171
4. The genetic variations of VAMP2, Synaptotagmin XI might be indication of the relationship between these genes and idiopathic generalized epilepsy PMID: 24164654
5. parkin interacts with and ubiquitinates synaptotagmin XI PMID: 12925569
6. Lack of disease-causing mutations in a detailed analysis of a large sample of familial and sporadic Parkinson's disease patients argues against a major role of mutations in the synaptotagmin XI gene in PD. PMID: 15354386
7. Excessive expression of Syt11 can be associated with schizophrenia. PMID: 17192956

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HGNC: 19239

OMIM: 608741

KEGG: hsa:23208

STRING: 9606.ENSP00000357307

UniGene: Hs.32984