SZT2 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA735962LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SZT2 Polyclonal antibody

Uniprot No.

Q5T011

Target Names

SZT2

Alternative Names

Chromosome 1 open reading frame 84 antibody; FLJ34502 antibody; Hypothetical protein LOC23334 antibody; Protein SZT2 antibody; RP11-506B15.1 antibody; Seizure threshold 2 homolog A antibody; Seizure threshold 2 protein homolog antibody; SZT2 antibody; SZT2_HUMAN antibody; SZT2A antibody; Uncharacterized protein KIAA0467 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein SZT2 protein (2396-2517AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. May play a role in the cellular response to oxidative stress.

Gene References into Functions

SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment PMID: 28199315
We conclude that the disruption of SZT2 with some residual function might lead to mild or moderate intellectual disability without seizures. PMID: 24324832
mutations in SZT2 cause a severe type of autosomal-recessive infantile encephalopathy. PMID: 23932106

Involvement in disease

Epileptic encephalopathy, early infantile, 18 (EIEE18)

Subcellular Location

Lysosome membrane. Peroxisome.

Tissue Specificity

Expressed in the brain, predominantly in the parietal and frontal cortex, as well as in dorsal root ganglia. Expressed in peripheral white blood cells.

Database Links

HGNC: 29040

OMIM: 615463

KEGG: hsa:23334

STRING: 9606.ENSP00000457168

UniGene: Hs.643560

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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