TAF12 Antibody

Code CSB-PA624102ESR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA624102ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA624102ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TAF12 Polyclonal antibody
Uniprot No. Q16514
Target Names TAF12
Alternative Names TAF12 antibody; TAF12 RNA polymerase II; TATA box binding protein (TBP)-associated factor; 20kDa antibody; TAF12_HUMAN antibody; TAF15 antibody; TAF2J antibody; TAFII 20/TAFII 15 antibody; TAFII-20/TAFII-15 antibody; TAFII20 antibody; TAFII20/TAFII15 antibody; Transcription initiation factor TFIID 20/15 kDa subunits antibody; Transcription initiation factor TFIID subunit 12 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Transcription initiation factor TFIID subunit 12 protein (1-161AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.
Gene References into Functions
  1. Ectopic expression of the TAF4 histone-fold fragment can efficiently squelch TAF12 in cells PMID: 29316427
  2. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1 PMID: 27551064
  3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
  4. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD. PMID: 23426901
  5. TAF12 hitherto regarded as RNA polymerase II (RNAP II)-specific was found to be also involved in RNAP I transcription. PMID: 17268553

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Subcellular Location Nucleus
Protein Families TAF12 family
Tissue Specificity Ubiquitous.
Database Links

HGNC: 11545

OMIM: 600773

KEGG: hsa:6883

STRING: 9606.ENSP00000263974

UniGene: Hs.530251

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