TAF6 Antibody

Datasheet

Code	CSB-PA023095LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA023095LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TAF6 Polyclonal antibody

Uniprot No.

P49848

Target Names

TAF6

Alternative Names

TAF6 antibody; TAF2E antibody; TAFII70 antibody; Transcription initiation factor TFIID subunit 6 antibody; RNA polymerase II TBP-associated factor subunit E antibody; Transcription initiation factor TFIID 70 kDa subunit antibody; TAF(II)70 antibody; TAFII-70 antibody; TAFII70 antibody; Transcription initiation factor TFIID 80 kDa subunit antibody; TAF(II)80 antibody; TAFII-80 antibody; TAFII80 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TAF6 Antibody (Product code: CSB-PA023095LA01HU) is Non-conjugated. For TAF6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA023095LB01HU	TAF6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA023095LC01HU	TAF6 Antibody, FITC conjugated
Biotin	CSB-PA023095LD01HU	TAF6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.; Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA.

Gene References into Functions

data point to several new RNA elements that can modulate TAF6delta and also reveal a role for RNA secondary structure in the selection of TAF6delta PMID: 25025302
The transcriptome data uncovered novel links between TAF6delta expression and the Notch, oxidative stress response, integrin, p53, p53 feedback loop 2, and angiogenesis pathways. PMID: 20096117
a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a PMID: 15328371
TAF6delta has a pivotal node in a signaling pathway that controls gene expression programs and apoptosis in the absence of p53 PMID: 18628956

Involvement in disease

Alazami-Yuan syndrome (ALYUS)

Subcellular Location

Nucleus.; [Isoform 4]: Nucleus.

Protein Families

TAF6 family

Database Links

HGNC: 11540

OMIM: 602955

KEGG: hsa:6878

STRING: 9606.ENSP00000399982

UniGene: Hs.489309

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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