TAPBPL Antibody, HRP conjugated

1. soluble TAPBPR, consisting of the luminal domain alone, added to intact cells, also functions as an effective peptide editor on surface MHC I molecules. PMID: 30213851
2. this study reports the crystal structure of MHC I in complex with the peptide editor TAPBPR (TAP-binding protein-related), a tapasin homolog. PMID: 29025991
3. this study presents the x-ray structure of the TAPBPR-MHC I complex, which delineates the central step of catalysis. PMID: 29025996
4. The authors identify an interaction between TAPBPR and UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1), a folding sensor in the calnexin/calreticulin quality control cycle that is known to regenerate the Glc1Man9GlcNAc2 moiety on glycoproteins. The results suggest the formation of a multimeric complex, dependent on a conserved cysteine at position 94 in TAPBPR, in which TAPBPR promotes the association of UGT1 with p PMID: 28425917
5. It is now clear there are two MHC class I specific peptide editors, tapasin and TAPBPR, intimately involved in controlling peptide presentation to the immune system. PMID: 26439010
6. These results support a role of TAPBPR in stabilizing peptide-receptive conformation(s) of MHC-I, permitting peptide editing. PMID: 26869717
7. TAPBPR is a new player in the MHC class I presentation pathway. (Review) PMID: 25720504
8. The longer TAPBPR protein interacted with MHC class I but was attenuated in its ability to down-regulate surface expression of MHC class I. PMID: 24444341
9. the data indicate that TAPBPR and tapasin bind in a similar orientation to the same face of MHC class I. PMID: 24163410
10. The function of the tapasin-related protein, TAPBPR, was investigated. PMID: 23401559

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HGNC: 30683

OMIM: 607081

KEGG: hsa:55080

STRING: 9606.ENSP00000266556

UniGene: Hs.504597